Saltar al contenido
Merck
Todas las fotos(1)

Key Documents

View All Documentation

M7316

Sigma-Aldrich

Monoamine Oxidase A human

recombinant, expressed in baculovirus infected BTI insect cells

Sinónimos:

MAO-A, MAOA

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Comisión internacional de enzimas:
1.4.3.4 (BRENDA, IUBMB)
MDL number:
MFCD04040932
UNSPSC Code:
12352204
NACRES:
NA.54

recombinant

expressed in baculovirus infected BTI insect cells

Quality Level

100

form

liquid

packaging

vial of ~2.5 mg

UniProt accession no.

P21397

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... MAOA(4128)

General description

Monoamine Oxidase A contains binding sites for 8α-S-cysteinyl-FAD.
Monoamine oxidases metabolize biogenic amines in the central nervous system and the peripheral tissue.

Application

Monoamine Oxidase A has been used in a study to assess abnormal behavior in a large kindred of males where a deficiency of enzymatic activity of monamine oxidase A was found. It has also been used in a study to investigate an association between smoking and the inhibition of MAOA.

Biochem/physiol Actions

MAO′s are proteins of the mitochondrial membrane. These enzymes are responsible for catalyzing oxidative deamination of endo- and xenobiotic amines. Substrate specificity differs for each isozyme.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

J S Fowler et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(24), 14065-14069 (1996-11-26)
Several studies have documented a strong association between smoking and depression. Because cigarette smoke has been reported to inhibit monoamine oxidase (MAO) A in vitro and in animals and because MAO A inhibitors are effective antidepressants, we tested the hypothesis
Ryuichi Harada et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 62(2), 253-258 (2020-07-11)
Reactive astrocytes play a key role in the pathogenesis of various neurodegenerative diseases. Monoamine oxidase-B (MAO-B) is one of the promising targets for the imaging of astrogliosis in the human brain. A novel selective and reversible MAO-B tracer, (S)-(2-methylpyrid-5-yl)-6-[(3-18F-fluoro-2-hydroxy)propoxy]quinoline (18F-SMBT-1)
Wenping Wang et al.
Antioxidants (Basel, Switzerland), 10(10) (2021-10-24)
Neurotransmitter catecholamines (dopamine, epinephrine, and norepinephrine) are liable to undergo oxidation, which copper is deeply involved in. Catecholamine oxidation-derived neurotoxicity is recognized as a pivotal pathological mechanism in neurodegenerative diseases. Glutamate, as an excitatory neurotransmitter, is enriched in the brain
Marcus A Maher et al.
Analytical and bioanalytical chemistry, 408(3), 695-703 (2015-11-18)
The need for rapid and cost-effective pre-screening protocols of the toxicological response of the vast array of emerging nanoparticle types is apparent and the emerging consensus on the paradigm of oxidative stress by generation of intracellular reactive oxygen species as
Vittorio Canale et al.
European journal of medicinal chemistry, 208, 112765-112765 (2020-09-20)
The complex etiology of Alzheimer's disease has initiated a quest for multi-target ligands to address the multifactorial causes of this neurodegenerative disorder. In this context, we designed dual-acting 5-HT6 receptor (5-HT6R) antagonists/MAO-B inhibitors using pharmacophore hybridization strategy. Our approach involved
Ver todos los artículos relacionados

Artículos

Serotonin Synthesis & Metabolism

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

Serotonin Synthesis & Metabolism

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

Serotonin Synthesis & Metabolism

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

Serotonin Synthesis & Metabolism

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico