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M6524

Sigma-Aldrich

Methoxamine hydrochloride

Sinónimos:

α-(1-Aminoethyl)-2,5-dimethoxybenzyl alcohol hydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C11H17NO3 · HCl
Número de CAS:
61-16-5
Peso molecular:
247.72
Número CE:
200-499-7
Número MDL:
MFCD00058607
Código UNSPSC:
12352116
ID de la sustancia en PubChem:
24277785
NACRES:
NA.77

Nivel de calidad

200

temp. de almacenamiento

2-8°C

cadena SMILES

Cl[H].COc1ccc(OC)c(c1)C(O)C(C)N

InChI

1S/C11H17NO3.ClH/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3;/h4-7,11,13H,12H2,1-3H3;1H

Clave InChI

YGRFXPCHZBRUKP-UHFFFAOYSA-N

Información sobre el gen

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

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Acciones bioquímicas o fisiológicas

α1-adrenoceptor agonist.

Características y beneficios

This compound is featured on the α1-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000385127
0000374683
0000324452
0000374683
0000385127

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Sven Francque et al.
Laboratory investigation; a journal of technical methods and pathology, 92(10), 1428-1439 (2012-08-15)
Non-alcoholic fatty liver disease can progress to steatohepatitis and fibrosis, and is also associated with impaired liver regeneration. The pathophysiology remains elusive. We recently showed that severe steatosis is associated with an increase in portal pressure, suggesting liver flow impairment.
Chandana B Herath et al.
American journal of physiology. Gastrointestinal and liver physiology, 304(1), G99-108 (2012-10-23)
Recent studies have shown that, in cirrhosis, portal angiotensin-(1-7) [Ang-(1-7)] levels are increased and hepatic expression of angiotensin converting enzyme 2 (ACE2) and the Mas receptor are upregulated, but the effects of Ang-(1-7) on hepatic hemodynamics in cirrhosis have not
Robert H Thiele et al.
Anesthesia and analgesia, 113(2), 284-296 (2011-04-27)
Phenylephrine and methoxamine are direct-acting, predominantly α(1) adrenergic receptor (AR) agonists. To better understand their physiologic effects, we screened 463 articles on the basis of PubMed searches of "methoxamine" and "phenylephrine" (limited to human, randomized studies published in English), as
Jiun-Jr Wang et al.
The Canadian journal of cardiology, 29(2), 243-253 (2012-05-25)
Using the reservoir-wave approach, we studied wave propagation, reflection, and re-reflection in the canine aorta with administrations of sodium nitroprusside (NP) and methoxamine (Mtx). In 8 anaesthetized dogs, excess pressures were calculated from pressure and flow measurements at 4 locations
Alain Frigon et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(15), 5579-5588 (2011-04-15)
Extra forces or torques are defined as forces or torques that are larger than would be expected from the input or stimuli, which can be mediated by properties intrinsic to motoneurons and/or to the muscle. The purpose of this study
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