M0317
Microsomes from Liver, Pooled
from human
Sinónimos:
Liver Microsomes
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About This Item
UNSPSC Code:
12161501
NACRES:
NA.47
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Application
Microsomes from liver have been used to study the in vitro effect of Clinacanthus nutans leaves on the activity of cytochrome P450 3A4 and 2E1.
Biochem/physiol Actions
Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.
Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Drug metabolism and pharmacokinetics, 33(1), 67-76 (2017-12-16)
This study aimed to investigate the liver microsomal inhibitory effects of silybin, silychristin, andrographolide, and curcumin by using morphine as an in vitro UGT2B7 probe substrate, and predict the magnitude of the herb-drug interaction arising from these herbal constituents' inhibition in vivo.
Cytotoxicity and cytochrome P450 inhibitory activities of Clinacanthus nutans
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