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L9668

Sigma-Aldrich

Lidoflazine

≥98% (HPLC), powder

Sinónimos:

4-[4,4-Bis(4-fluorophenyl)butyl]-N-(2,6-dimethylphenyl)-1-piperazineacetamide

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About This Item

Fórmula empírica (notación de Hill):
C30H35F2N3O
Número de CAS:
3416-26-0
Peso molecular:
491.62
Número CE:
222-312-8
Número MDL:
MFCD00057353
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329817673
NACRES:
NA.77

Nivel de calidad

100

Ensayo

≥98% (HPLC)

Formulario

powder

color

white

solubilidad

DMSO: ≥10 mg/mL

temp. de almacenamiento

2-8°C

cadena SMILES

Cc1cccc(C)c1NC(=O)CN2CCN(CCCC(c3ccc(F)cc3)c4ccc(F)cc4)CC2

InChI

1S/C30H35F2N3O/c1-22-5-3-6-23(2)30(22)33-29(36)21-35-19-17-34(18-20-35)16-4-7-28(24-8-12-26(31)13-9-24)25-10-14-27(32)15-11-25/h3,5-6,8-15,28H,4,7,16-21H2,1-2H3,(H,33,36)

Clave InChI

ZBIAKUMOEKILTF-UHFFFAOYSA-N

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Acciones bioquímicas o fisiológicas

HERG calcium channel blocker
Lidoflazine is an antianginal calcium channel blocker that carries a significant risk of QT interval prolongation and ventricular arrhythmia. It prolongs QT interval by blocking HERG channel. IC50 < 0.1 μM

Características y beneficios

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
0000419384
0000419384
127K4606V
0000073818
127K4606V

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Vijaya M Musini et al.
The Cochrane database of systematic reviews, 6, CD000028-CD000028 (2019-06-06)
This is the second substantive update of this review. It was originally published in 1998 and was previously updated in 2009. Elevated blood pressure (known as 'hypertension') increases with age - most rapidly over age 60. Systolic hypertension is more
P Vaagenes et al.
Resuscitation, 35(1), 41-52 (1997-08-01)
We explored the hypothesis that brain damage after cardiac arrest caused by ventricular fibrillation (VF) needs different therapies than that after asphyxiation, which has been studied less thoroughly. In 67 healthy mongrel dogs of both sexes cardiac arrest (at normothermia)
L Noyez et al.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 6(7), 377-381 (1992-01-01)
The concept of pretreatment of the myocardium with a pharmacological agent protecting the cell against ischemic and reperfusion injury is very attractive. Lidoflazine, a calcium overload blocker, predominantly membrane stabilizing, is able to prevent cell damage during ischemic arrest and
J Jacobsson et al.
Cryobiology, 29(3), 305-309 (1992-06-01)
The purpose of this study was to investigate the possibility of improving the organ preservation properties of the University of Wisconsin (UW) solution by adding the calcium entry blocker lidoflazine. We also investigated the possibility of decreasing the cold ischemia
John M Ridley et al.
Journal of molecular and cellular cardiology, 36(5), 701-705 (2004-05-12)
Lidoflazine is an antianginal calcium channel blocker that carries a significant risk of QT interval prolongation and ventricular arrhythmia. We investigated whether or not lidoflazine inhibits current through the rapid delayed rectifier K(+) channel alpha subunit (encoded by HERG -
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