Saltar al contenido
Merck

K1757

Sigma-Aldrich

Keratinocyte Growth Factor human

≥95% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, powder, suitable for cell culture

Sinónimos:

hFGF-7, hKGF, FGF-7, KGF

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización


About This Item

Número de CAS:
Número MDL:
Código UNSPSC:
12352202
NACRES:
NA.77

Nombre del producto

Keratinocyte Growth Factor human, KGF, recombinant, expressed in E. coli, powder, suitable for cell culture

origen biológico

human

Nivel de calidad

recombinante

expressed in E. coli

Ensayo

≥95% (SDS-PAGE and HPLC)

Formulario

powder

potencia

0.1-15 ng/mL ED50/EC50

calidad

endotoxin tested

mol peso

18.9 kDa

envase

pkg of 10 and 50 μg

técnicas

cell culture | mammalian: suitable

impurezas

1 EU/μg

Nº de acceso UniProt

temp. de almacenamiento

−20°C

Información sobre el gen

human ... FGF7(2252)

¿Está buscando productos similares? Visita Guía de comparación de productos

Descripción general

Keratinocyte Growth Factor(KGF) is a 18.9 kDa growth factor, spanning 163 amino acids, belongs to the fibroblast growth factor family. It includes a secretory signal sequence and shares 39% identity with FGF-Basic. It is expressed in a number of stromal fibroblast cell lines, mesenchymal cells but absent from normal glial cells and epithelial cell lines.

Aplicación

Keratinocyte Growth Factor human has been used:
  • as a component of epithelial growth medium
  • as a positive control for antigen to determine the activity of the antibody
  • to analyze the influence of KGF associated with thermo-sterilized carboxymethyl chitosan (NOCCts) in the reduction of pericardial adhesions

Acciones bioquímicas o fisiológicas

Keratinocyte Growth Factor(KGF) stimulates proliferation and differentiation of keratinocytes and other cells in the epithelium. It induces chemotaxis of microvascular endothelial cells and neovascularization of rat cornea. It stimulates the hyaluronic acid synthesis in proliferating and migrating basal cells. KGF contributes to the survival of cells under stress conditions. KGF is highly expressed in injured and inflamed epithelial cells, thereby, promotes wound healing.

Forma física

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.5 mg bovine serum albumin.

Nota de análisis

Determined by a cell proliferation assay using 4MBr-5 cells.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves


Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number

¿No ve la versión correcta?

Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Synergism between keratinocyte growth factor and carboxymethyl chitosan reduces pericardial adhesions
Lopes JB, et al.
The Annals of Thoracic Surgery, 90(2), 566-572 (2010)
Stimulation of in vivo angiogenesis by in situ crosslinked, dual growth factor-loaded, glycosaminoglycan hydrogels
Elia R, et al.
Biomaterials, 31(17), 4630-4638 (2010)
Characteristics of MIC-1 antlerogenic stem cells and their effect on hair growth in rabbits.
Cegielski M, et al.
In Vivo, 27(1), 97-106 (2013)
P Gillis et al.
Journal of cell science, 112 ( Pt 12), 2049-2057 (1999-05-26)
Keratinocyte growth factor (KGF), also called fibroblast growth factor-7, is widely known as a paracrine growth and differentiation factor that is produced by mesenchymal cells and has been thought to act specifically on epithelial cells. Here it is shown to
Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration
Alpdogan O, et al.
Blood, 107(6), 2453-2460 (2006)

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico