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I9759

Sigma-Aldrich

Ile-Pro-Ile

≥97% (HPLC)

Sinónimos:

Diprotin A

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About This Item

Fórmula empírica (notación de Hill):
C17H31N3O4
Número de CAS:
90614-48-5
Peso molecular:
341.45
MDL number:
MFCD00038707
UNSPSC Code:
51111800
PubChem Substance ID:
24896160
NACRES:
NA.77
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Quality Level

200

assay

≥97% (HPLC)

form

powder

solubility

water: 1 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

CCC(C)C(N)C(=O)N1CCCC1C(=O)NC(C(C)CC)C(O)=O

InChI

1S/C17H31N3O4/c1-5-10(3)13(18)16(22)20-9-7-8-12(20)15(21)19-14(17(23)24)11(4)6-2/h10-14H,5-9,18H2,1-4H3,(H,19,21)(H,23,24)

InChI key

JNTMAZFVYNDPLB-UHFFFAOYSA-N

Categorías relacionadas

Amino Acid Sequence

Ile-Pro-Ile

Application

Ile-Pro-Ile has been used as a supplement for blood collection for hormone measurement[1] and used in Islets cell culture to stabilize glucagon-like peptide-1 (GLP-1).[2] It has also been used to inhibit the breakdown of gonadotropin-inhibitory hormone (GnIH) following serum collection.[3]

Biochem/physiol Actions

Dipeptidyl peptidase IV Inhibitor. Inhibits entry of HIV-1 or HIV-2
Inhibitor of dipeptidyl peptidase IV. Inhibits entry of HIV-1 or HIV-2 into T lymphoblastoid and monocytoid cell lines.

Features and Benefits

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000289713
0000289713
SLCH8910
SLBZ3509
SLBZ0291

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Pancreatic alpha cell-derived glucagon-related peptides are required for beta cell adaptation and glucose homeostasis
Traub S, et al.
Cell Reports, 18(13), 3192-3203 (2017)
Brandon L Panaro et al.
Molecular metabolism, 19, 65-74 (2018-11-28)
Fibroblast Activation Protein (FAP), an enzyme structurally related to dipeptidyl peptidase-4 (DPP-4), has garnered interest as a potential metabolic drug target due to its ability to cleave and inactivate FGF-21 as well as other peptide substrates. Here we investigated the
Pádraigín A Harnedy et al.
Food research international (Ottawa, Ont.), 106, 598-606 (2018-03-28)
Large quantities of low-value protein rich co-products, such as salmon skin and trimmings, are generated annually. These co-products can be upgraded to high-value functional ingredients. The aim of this study was to assess the antidiabetic potential of salmon skin gelatin
Chao-Hung Wang et al.
Journal of molecular and cellular cardiology, 41(1), 34-43 (2006-05-09)
Enalapril, an angiotensin-converting enzyme (ACE) inhibitor, reduces cardiovascular events in patients with acute myocardial infarction. However, whether the beneficial effect of enalapril is mediated in part through endothelial progenitor cells (EPCs) has yet to be elucidated. This study investigated the
Lucianno Carneiro et al.
Nutrients, 14(7) (2022-04-13)
Nausea, vomiting and abdominal pain in diabetic patients are often attributed to diabetic gastropathy (DG). Post-pyloric ("jejunal") enteral nutrition (JN) may improve nutrition and glycaemia in difficult cases. The acute effects of JN on postprandial symptoms and gastric function in
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