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Key Documents

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I3636

Sigma-Aldrich

Acridine Mutagen ICR 191

Sinónimos:

6-Chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C19H21Cl2N3O · 2HCl
Número de CAS:
17070-45-0
Peso molecular:
451.22
Beilstein/REAXYS Number:
8176205
EC Number:
241-129-4
MDL number:
MFCD00013320
UNSPSC Code:
12171500
PubChem Substance ID:
24896042
NACRES:
NA.32

solubility

DMSO: soluble

Quality Level

200

suitability

suitable for Ames test in Salmonella and E. coli (Frameshift mutagenic standard)

storage temp.

2-8°C

SMILES string

Cl[H].Cl[H].COc1ccc2nc3cc(Cl)ccc3c(NCCCNCCCl)c2c1

InChI

1S/C19H21Cl2N3O.2ClH/c1-25-14-4-6-17-16(12-14)19(23-9-2-8-22-10-7-20)15-5-3-13(21)11-18(15)24-17;;/h3-6,11-12,22H,2,7-10H2,1H3,(H,23,24);2*1H

InChI key

LMEMIKWTNPWYMI-UHFFFAOYSA-N

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pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Carc. 1B

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificados de análisis (COA)

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Richard Hampson et al.
Mutation research, 525(1-2), 1-9 (2003-03-26)
Mutagenesis screening, in which heritable traits are isolated following damage to the genome, is a powerful approach for investigating gene function. Among vertebrate model organisms, the zebrafish (Danio rerio) is ideally suited to mutagenesis screens. The success of large-scale screens
S A Amundson et al.
Mutation research, 284(2), 287-295 (1992-12-16)
Human lymphoblastoid cell lines derived from WI-L2 exhibit unexpected frequencies of diaminopurine (DAP) resistant mutants. The background mutant fractions of 10(-7) to 10(-8) in untreated cultures are much lower than the frequencies expected for loss of a heterozygous autosomal locus
S De Flora et al.
Mutagenesis, 12(6), 431-435 (1997-12-31)
Multiple drug resistance (MDR) mechanisms are known to limit the effectiveness of some cancer chemotherapies, probably through enhancing P-glycoprotein-mediated drug efflux from mammalian cells. Similar mechanisms appear to act in other organisms, including bacteria, and may affect not only the
Kathryn Annett et al.
Experimental gerontology, 40(12), 976-981 (2005-10-12)
T cells undergo rapid clonal expansion upon antigenic stimulation to produce an effective immune response. Any defect in the DNA mismatch repair (MMR) system may have a detrimental effect on T cell proliferation. This study employed an in vitro model
W D Chen et al.
Journal of the National Cancer Institute, 92(6), 480-485 (2000-03-16)
Deficiency of DNA mismatch repair is a common feature of cancers exhibiting instability of microsatellite DNA sequences. Cancers with microsatellite instability are recognizable by their high rate of spontaneous frameshift mutations within microsatellite sequences, their resistance to killing by cytotoxic
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