Saltar al contenido
Merck
Todas las fotos(3)

Key Documents

HPA049374

Sigma-Aldrich

Anti-SNX6 antibody produced in rabbit

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Sinónimos:

Anti-sorting nexin 6

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización


About This Item

UNSPSC Code:
12352203
Human Protein Atlas Number:
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

technique(s)

immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:50-1:200

immunogen sequence

RLGAAMMEGLDDGPDFLSEEDRGLKAINVDLQSDAALQVDISDALSE

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SNX6(58533)

General description

Sorting nexin 6 (SNX6) has N-terminal phosphoinositide‐binding phox homology (PX) domain and a C-terminal BAR (Bin/amphiphysin/Rvc) domain. The SNX6 gene is mapped to human chromosome 14q13.1. It is expressed in two isoforms and has high expression in heart, skeletal muscle, and placenta. It shows low expression in lungs and liver.

Immunogen

sorting nexin 6 recombinant protein epitope signature tag (PrEST)

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.

Biochem/physiol Actions

Sorting nexin 6 (SNX6) is involved in endosomal sorting. It interacts with receptor serine-threonine kinases and transforming growth factor-β (TGF-β) family of peptides. It coordinates with sorting nexin 5 (SNX5) and hinders phosphatidylinositol phosphate kinases (PIPKIγi5)-mediated E-cadherin degradation. SNX6 mediates the transport of cation-independent mannose-6-phosphate (CI-MPR) from endosome to trans-Golgi-network. SNX6 interacts with dynein motor complex and regulates the formation of tubular retrograde intermediates. SNX6 interacts with lamin A and regulates its synthesis and incorporation into the nuclear envelope.

Features and Benefits

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST85090

Physical form

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

¿No encuentra el producto adecuado?  

Pruebe nuestro Herramienta de selección de productos.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Sorting nexin 6 enhances lamin a synthesis and incorporation into the nuclear envelope
Gonzalez-Granado JM, et al.
PLoS ONE, 9(12), e115571-e115571 (2014)
PIPKIgammai5 regulates the endosomal trafficking and degradation of E-cadherin
Schill NJ, et al.
Journal of Cell Science, jcs-132423 (2014)
A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer
Wassmer T, et al.
Journal of Cell Science, 120(1), 45-54 (2007)
Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules
Van W, et al.
The Embo Journal, 31(23), 4466-4480 (2012)
14q13. 1-21.1 deletion encompassing the HPE8 locus in an adolescent with intellectual disability and bilateral microphthalmia, but without holoprosencephaly
Piccione M, et al.
American Journal of Medical Genetics. Part A, 158(6), 1427-1433 (2012)

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico