Saltar al contenido
Merck
Todas las fotos(1)

Key Documents

View All Documentation

H1007

Sigma-Aldrich

L-Homoarginine hydrochloride

≥98% (TLC)

Sinónimos:

(S)-2-Amino-6-guanidinohexanoic acid hydrochloride

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Fórmula lineal:
H2NC(=NH)NH(CH2)4CH(NH2)CO2H · HCl
Número de CAS:
1483-01-8
Peso molecular:
224.69
Beilstein/REAXYS Number:
4016621
EC Number:
216-045-6
MDL number:
MFCD00012622
UNSPSC Code:
12352209
PubChem Substance ID:
24895420
NACRES:
NA.26

product name

L-Homoarginine hydrochloride, unnatural arginine analog

Quality Level

200

assay

≥98% (TLC)

form

powder

color

white to off-white

mp

213-215 °C (lit.)

solubility

H2O: soluble

application(s)

peptide synthesis

SMILES string

Cl[H].N[C@@H](CCCCNC(N)=N)C(O)=O

InChI

1S/C7H16N4O2.ClH/c8-5(6(12)13)3-1-2-4-11-7(9)10;/h5H,1-4,8H2,(H,12,13)(H4,9,10,11);1H/t5-;/m0./s1

InChI key

YMKBVNVCKUYUDM-JEDNCBNOSA-N

¿Está buscando productos similares? Visita Guía de comparación de productos

Application

L-Homoarginine may be used to create non-natural proteins for studies of post-translational protein modifications. Arginine residues are often located at the active centers of proteins and enzymes. Replacing these arginines with homoarginine can elucidate protein function and structural requirements. L-Homoarginine is used to study the mechanisms of nitric oxide production by cells via nitric oxide synthase(s). L-Homoarginine is used as a selective mammalian alkaline phosphatase isoenzyme inhibitor. The substitution of homoarginine for arginine or lysine renders proteins resistant to proteolysis by trypsin.
The substitution of homoarginine for arginine or lysine renders proteins resistant to proteolysis by trypsin. Arginine residues are often located at the active centers of proteins and enzymes. Replacing these arginines with homoarginine can elucidate protein function and structural requirements.

Biochem/physiol Actions

Homoarginine is an inhibitor of tissue nonspecific alkaline phosphatase (TNALP). It is also an inhibitor of cellular transport of arginine by a sodium-independent high affinity y+ transporter.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Szilvia Erdélyi-Bótor et al.
Cephalalgia : an international journal of headache, 37(6), 571-580 (2016-05-22)
Background/Aim Migraine is a risk factor for the formation of silent brain white matter lesions (WMLs) that are possibly ischemic in nature. Although dysfunction of the L-arginine/nitric oxide (NO) pathway has been associated with oxidative stress and endothelial dysfunction in
Azin Nowrouzi et al.
Biochemical and biophysical research communications, 330(2), 400-409 (2005-03-31)
Liver tissue is the source of 90% of serum alkaline phosphatase (AP). The serum levels and structures of tumor marker proteins change under many disease conditions as well as cancer. The study was aimed at determining the type of alkaline
Amino acids as modulators of endothelium-derived nitric oxide.
Kakoki M, Kim HS, Edgell CJ, et al.
American Journal of Physiology: Renal Physiology, 291, F297-F304 (2006)
J Fernandes et al.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 41(1), 41-46 (2007-12-22)
Our objective was to characterize the modulation of the activity of Saccharomyces cerevisiae alkaline phosphatases (ALPs) by classic inhibitors of ALP activity, cholesterol and steroid hormones, in order to identify catalytic similarities between yeast and mammalian ALPs. S. cerevisiae expresses
Michael D Wetzel et al.
Physiological reports, 9(5), e14766-e14766 (2021-03-14)
Recently we showed that homoarginine supplementation confers kidney protection in diabetic mouse models. In this study we tested whether the protective effect of homoarginine is nitric oxide synthase-3 (NOS3)-independent in diabetic nephropathy (DN). Experiments were conducted in NOS3 deficient (NOS3-/-
Ver todos los artículos relacionados

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico