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Merck

H0292

Sigma-Aldrich

HIV-1 Tat Peptide

≥97% (HPLC), lyophilized powder

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About This Item

Fórmula empírica (notación de Hill):
C64H118N32O14
Número de CAS:
Peso molecular:
1559.83
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.32

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product name

HIV-1 Tat Protein (47-57),

biological source

synthetic

Quality Level

form

lyophilized powder

solubility

deionized water: soluble

shipped in

dry ice

storage temp.

−20°C

SMILES string

NCCCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C64H118N32O14/c65-25-3-1-11-39(89-50(101)38(13-5-27-81-59(69)70)88-48(99)34-87-49(100)37(67)33-35-19-21-36(97)22-20-35)51(102)90-40(12-2-4-26-66)52(103)91-41(14-6-28-82-60(71)72)53(104)92-43(16-8-30-84-62(75)76)55(106)95-45(23-24-47(68)98)57(108)94-42(15-7-29-83-61(73)74)54(105)93-44(17-9-31-85-63(77)78)56(107)96-46(58(109)110)18-10-32-86-64(79)80/h19-22,37-46,97H,1-18,23-34,65-67H2,(H2,68,98)(H,87,100)(H,88,99)(H,89,101)(H,90,102)(H,91,103)(H,92,104)(H,93,105)(H,94,108)(H,95,106)(H,96,107)(H,109,110)(H4,69,70,81)(H4,71,72,82)(H4,73,74,83)(H4,75,76,84)(H4,77,78,85)(H4,79,80,86)/t37-,38-,39-,40-,41-,42-,43-,44-,45-,46-/m0/s1

InChI key

RAVVEEJGALCVIN-AGVBWZICSA-N

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Este artículo
T1331SCP0169SAB5700590
Tat-Beclin 1

T1331

Tat-Beclin 1

Quality Level

200

Quality Level

200

Quality Level

-

Quality Level

100

form

lyophilized powder

form

lyophilized powder

form

lyophilized

form

lyophilized powder

shipped in

dry ice

shipped in

dry ice

shipped in

-

shipped in

wet ice

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

deionized water: soluble

solubility

-

solubility

-

solubility

-

Amino Acid Sequence

Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg

General description

HIV-1 trans-activator of transcription (Tat) is an 11kDa protein,[1] which regulates HIV-1 gene expression at the level of transcription and protein synthesis. It is located in the nucleus of infected cells. HIV-1 Tat functions as a transcriptional activator for the synthesis of full-length viral RNA.[2] It induces RNA splicing.[3] Tat is an RNA binding protein, which particularly recognizes trans activator response element (TAR) from the HIV-1 RNA molecule.[4]

Biochem/physiol Actions

Synthetic peptide that includes the sequence responsible for the cellular uptake of the human immunodeficiency virus-1 Tat protein, consisting of the polycationic region 49–57. The peptide is part of the protein transduction domain (PTD) and was shown to enable the introduction of nucleic acids into cells.

Physical form

Lyophilized from 0.1% aqueous trifluoroacetate (TFA).

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class

11 - Combustible Solids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable


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Mechanism of HIV-1 Tat RNA translation and its activation by the Tat protein
Charnay N, et al.
Retrovirology, 6(1), 74-74 (2009)
Roles and functions of HIV-1 Tat protein in the CNS: an overview
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