GW21317
Anti-RGS12 (ab1) antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Sinónimos:
Anti-Regulator of G-protein signaling 12
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Productos recomendados
biological source
chicken
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, mouse, human
manufacturer/tradename
Genway 15-288-21317
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... RGS12(6002)
Categorías relacionadas
General description
Regulator of G-protein signaling 12 is a protein encoded by the RGS12 gene in humans belonging to the RGS protein family. It is a nuclear protein that exhibits a unique pattern of subnuclear organization into nuclear foci or dots when expressed endogenously or ectopically. RGS12 consists of alternatively spliced PDZ domain by which RGS proteins may target specific G-protein-coupled receptor systems for desensitization.
Immunogen
Immunogen Sequence: GI # 38327601, sequence 1372-1447
Recombinant regulator of G-protein signalling 12 isoform 1
Application
Anti-RGS12 (ab1) antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Regulator of G-protein signaling 12 plays a role during alternative splicing and cell cycle-dependent mechanisms in expression and subnuclear targeting of RGS12 proteins. RGS12 possesses a novel structure and function in the nucleus and the biological activities are distinct from those of other members of the RGS protein family.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Gongsheng Yuan et al.
Cell discovery, 6, 59-59 (2020-09-15)
Mitochondrial morphology and function are crucial for tissue homeostasis, such as for skeletal development, but the cellular and molecular mechanisms remain unclear. Here, we provide evidence that regulator of G-protein signaling 12 (RGS12) is present in the mitochondria of primary
Gongsheng Yuan et al.
Cell insight, 1(5), 100055-100055 (2023-05-17)
Angiogenesis is the formation of new capillaries that plays an essential role in the pathogenesis of inflammatory arthritis. However, the cellular and molecular mechanisms remain unclear. Here, we provide the first evidence that regulator of G-protein signaling 12 (RGS12) promotes
Tapan K Chatterjee et al.
Molecular and cellular biology, 22(12), 4334-4345 (2002-05-25)
RGS12TS-S, an 1,157-amino-acid RGS protein (regulator of G protein signaling), is a nuclear protein that exhibits a unique pattern of subnuclear organization into nuclear foci or dots when expressed endogenously or ectopically. We now report that RGS12TS-S is a nuclear
B E Snow et al.
The Journal of biological chemistry, 273(28), 17749-17755 (1998-07-04)
Regulator of G-protein signaling (RGS) proteins increase the intrinsic guanosine triphosphatase (GTPase) activity of G-protein alpha subunits in vitro, but how specific G-protein-coupled receptor systems are targeted for down-regulation by RGS proteins remains uncharacterized. Here, we describe the GTPase specificity
Anil Akturk et al.
Science advances, 8(42), eabq2826-eabq2826 (2022-10-20)
Inhibitory G proteins (GNAI/Gαi) bind to the scaffold G protein signaling modulator 2 (GPSM2) to form a conserved polarity complex that regulates cytoskeleton organization. GPSM2 keeps GNAI in a guanosine diphosphate (GDP)-bound state, but how GPSM2-GNAI is generated or relates
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