GS70
GST P1-1, Recombinant Human
Sinónimos:
DFN7, FAEES3, GST3, GSTP, HEL-S-22, glutathione S-transferase pi
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About This Item
Código UNSPSC:
12352200
NACRES:
NA.26
Productos recomendados
origen biológico
human
Nivel de calidad
recombinante
expressed in E. coli
Ensayo
>95% (SDS-PAGE)
Formulario
frozen liquid
actividad específica
60.45 units/mg protein
mol peso
23 kDa
temp. de almacenamiento
−70°C
Información sobre el gen
human ... GSTP1(2950)
Descripción general
using spectrophotometric determination of 1-chloro-2,4-dinitrobenzene (CDNB) conjugation with reduced glutathione (1.0 mM) in 100 mM KPO4 (pH 6.5) at room temperature.
Acciones bioquímicas o fisiológicas
Glutathione S-transferase pi 1 (GSTP1) is an enzyme that in humans is encoded by the GSTP1 gene. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.
This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.
Almacenamiento y estabilidad
The enzyme should be used by the end-user customer within 1 year of receipt.
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Numerous epidemiological studies have evaluated the association of Glutathione S-transferase P1 (GSTP1) Ile105Val polymorphism with the risk of skin cancer. However, the results remain inconclusive. To derive a more precise estimation of the association between the GSTP1 Ile105Val polymorphism and
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