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Key Documents

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G3002

Sigma-Aldrich

Gly-Pro

≥98%, suitable for ligand binding assays

Sinónimos:

glycyl-L-proline

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About This Item

Fórmula empírica (notación de Hill):
C7H12N2O3
Número de CAS:
704-15-4
Peso molecular:
172.18
EC Number:
211-880-2
UNSPSC Code:
12352202
PubChem Substance ID:
24895111
NACRES:
NA.26

product name

Gly-Pro,

assay

≥98%

Quality Level

200

form

solid

technique(s)

ligand binding assay: suitable

color

white

storage temp.

−20°C

SMILES string

NCC(N1[C@H](C(O)=O)CCC1)=O

InChI

1S/C7H12N2O3/c8-4-6(10)9-3-1-2-5(9)7(11)12/h5H,1-4,8H2,(H,11,12)

InChI key

KZNQNBZMBZJQJO-UHFFFAOYSA-N

Application


  • Diagnostic efficacy of [(68)Ga]Ga-DOTA-GPFAPI-04 in patients with solid tumors in a head-to-head comparison with [(18)F]F-FDG: results from a prospective clinical study.: This study explores the use of Gly-Pro in peptide imaging agents, specifically [(68)Ga]Ga-DOTA-GPFAPI-04, demonstrating its superior diagnostic performance in detecting solid tumors compared to traditional imaging modalities, offering new avenues for cancer diagnosis and monitoring (Yuan et al., 2024).

  • Understanding the Transepithelial Transport and Transbilayer Diffusion of the Antihypertensive Peptide Asn-Cys-Trp: Insights from Caco-2 Cell Monolayers and the DPPC Model Membrane.: This research demonstrates the utility of Gly-Pro in studying the absorption and metabolic stability of antihypertensive peptides, providing key insights into their pharmacokinetic behaviors and enhancing drug delivery strategies (Wu et al., 2024).

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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E Berardesca et al.
The British journal of dermatology, 126(2), 193-195 (1992-02-01)
A case is reported of a 15-year-old boy with prolidase deficiency and marked urinary excretion of the iminodipeptide gly-pro. Prolidase activity of erythrocytes against substrate glycyl-proline was deficient, but after blood transfusions this was increased to 15.7% of donor activity
Poonam Kalhotra et al.
Biomolecules, 10(2) (2020-02-23)
Diabetes mellitus is a severe health problem in Mexico, and its prevalence is increasing exponentially every year. Recently, DPP-4 (dipeptidyl peptidase-4) inhibitors have become attractive oral anti-hyperglycemic agents to reduce the pathology of diabetes. Gliptin's family, such as sitagliptin, vildagliptin
Mitsuru Tanaka et al.
Scientific reports, 9(1), 5769-5769 (2019-04-10)
Apart from nutrients required for the brain, there has been no report that naturally occurring peptides can cross the blood-brain barrier (BBB). The aim of this study was to identify the BBB-transportable peptides using in situ mouse perfusion experiments. Based
C Méthivier et al.
Faraday discussions, 204, 69-81 (2017-08-03)
Adsorption of the Glycine-Proline (Gly-Pro) dipeptide has been investigated using surface science complementary techniques on Au(110) and Ag(110), showing some interesting differences both in the chemical form and surface organization of the adsorbed peptide. On Au(110), Gly-Pro mainly adsorbs in
Min Fey Chek et al.
Scientific reports, 7(1), 5312-5312 (2017-07-15)
Polyhydroxyalkanoate (PHA) is a promising candidate for use as an alternative bioplastic to replace petroleum-based plastics. Our understanding of PHA synthase PhaC is poor due to the paucity of available three-dimensional structural information. Here we present a high-resolution crystal structure
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