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D2531

Sigma-Aldrich

Dextromethorphan hydrobromide monohydrate

≥99% (TLC)

Sinónimos:

d-3-Methoxy-N-methylmorphinan hydrobromide monohydrate, (9S,13S,14S)-3-Methoxy-17-methylmorphinan hydrobromide

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About This Item

Fórmula empírica (notación de Hill):
C18H25NO · HBr · H2O
Número de CAS:
6700-34-1
Peso molecular:
370.32
Beilstein/REAXYS Number:
6453793
MDL number:
MFCD02173901
UNSPSC Code:
12352200
PubChem Substance ID:
57654086
NACRES:
NA.77

Quality Level

200

assay

≥99% (TLC)

form

powder

SMILES string

Br[H].[H]O[H].[H][C@]12CCCC[C@]13CCN(C)[C@H]2Cc4ccc(OC)cc34

InChI

1S/C18H25NO.BrH.H2O/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18;;/h6-7,12,15,17H,3-5,8-11H2,1-2H3;1H;1H2/t15-,17+,18+;;/m1../s1

InChI key

STTADZBLEUMJRG-IKNOHUQMSA-N

Gene Information

human ... GRIN1(2902) , GRIN2A(2903) , GRIN2B(2904) , GRIN2C(2905) , GRIN2D(2906) , GRIN3A(116443) , GRIN3B(116444) , SIGMAR1(10280)

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Application

Dextromethorphan hydrobromide monohydrate has been used as a substrate for cytochrome P450 2D6 enzyme action, in potassium phosphate buffer for measuring P450 activity and is used in enzyme inhibition studies.

Biochem/physiol Actions

Dextromethorphan hydrobromide is an allosteric antagonist at N-methyl D- aspartate (NMDA)-controlled ion channels and antagonist at voltage-dependent channels. Dextromethorphan hydrobromide is useful in treating dry cough.

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

hcodes

H301,H411

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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In Vitro Inhibition and Induction of Human Liver Cytochrome P450 Enzymes by Gentiopicroside: Potent Effect on CYP2A6
Deng Y, et al.
Drug Metabolism and Pharmacokinetics, 28(4), 339-344 (2013)
T Zimmermann et al.
Arzneimittel-Forschung, 45(1), 41-43 (1995-01-01)
The polymorphism of dextromethorphan (CAS 125-71-3) metabolism is dependent on hepatic cytochrom P4502D6 (CYP2D6) activity. The relationship between the CYP2D6 genotype and the dextromethorphan phenotype was studied in 83 healthy unrelated subjects. Genotype was determined by allele-specific polymerase chain reaction
Dependence on dextromethorphan hydrobromide.
Fleming Philip M
British Medical Journal (Clinical Research ed.), 293(6547), 597-597 (1986)
The effect of prototypic sigma ligands on the binding of [3H]dextromethorphan to guinea pig brain.
Klein, et al.
Neuroscience Letters, 91, 175-175 (1989)
J M Musacchio et al.
Life sciences, 45(19), 1721-1732 (1989-01-01)
There is increasing evidence that sigma ligands and dextromethorphan (DM) bind to at least one common high-affinity site. DM and other antitussives do not produce psychotomimetic effects. This suggested that sigma ligands may produce their characteristic effects through another site
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