Saltar al contenido
Merck
Todas las fotos(1)

Key Documents

View All Documentation

C6240

Sigma-Aldrich

CITCO

≥98% (HPLC), solid

Sinónimos:

6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Fórmula empírica (notación de Hill):
C19H12N3OCl3S
Número de CAS:
338404-52-7
Peso molecular:
436.74
MDL number:
MFCD00139608
UNSPSC Code:
12352203
PubChem Substance ID:
24724448
NACRES:
NA.77

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

solubility

DMSO: soluble 28 mg/mL
H2O: insoluble

storage temp.

−20°C

SMILES string

Clc1ccc(cc1)-c2nc3sccn3c2\C=N\OCc4ccc(Cl)c(Cl)c4

InChI

1S/C19H12Cl3N3OS/c20-14-4-2-13(3-5-14)18-17(25-7-8-27-19(25)24-18)10-23-26-11-12-1-6-15(21)16(22)9-12/h1-10H,11H2/b23-10+

Inchi Key

ZQWBOKJVVYNKTL-AUEPDCJTSA-N

General description

CITCO is an imidazothiazole derivative. It stimulates human constitutive androstane receptor (CAR) nuclear translocation.

Application

CITCO has been used for the activation of mouse constitutive androstane receptor (CAR) and human CAR.

Biochem/physiol Actions

CITCO is a constitutive androstane receptor (CAR) agonist; nuclear receptor NR113 agonist.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Tadeja Režen et al.
Drug metabolism and disposition: the biological fate of chemicals, 45(8), 974-976 (2017-05-26)
Statins are well known lipid lowering agents that inhibit the enzyme 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase. They also activate drug metabolism but their exact receptor-mediated action has not been proven so far. We tested whether atorvastatin and rosuvastatin are direct ligands of
Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes
Maglich JM, et al.
The Journal of Biological Chemistry, 278(19), 17277-17283 (2003)
Won-Gu Choi et al.
Pharmaceutics, 12(3) (2020-03-07)
Mertansine, a tubulin inhibitor, is used as the cytotoxic component of antibody-drug conjugates (ADCs) for cancer therapy. The effects of mertansine on uridine 5'-diphospho-glucuronosyltransferase (UGT) activities in human liver microsomes and its effects on the mRNA expression of cytochrome P450s
Jodi M Maglich et al.
The Journal of biological chemistry, 278(19), 17277-17283 (2003-03-04)
The orphan nuclear constitutive androstane receptor (CAR) is proposed to play a central role in the response to xenochemical stress. Identification of CAR target genes in humans has been limited by the lack of a selective CAR agonist. We report
Constitutive androstane receptor agonist CITCO inhibits growth and expansion of brain tumour stem cells
Chakraborty S , et al.
British Journal of Cancer, 104(3), 448-448 (2011)
Ver todos los artículos relacionados

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico