C213140
DMT-2′O-Methyl-rC(ac) Phosphoramidite
configured for MerMade
Sinónimos:
N-acetyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-methyl-cytidine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
About This Item
Productos recomendados
biological source
non-animal source (no BSE/TSE risk)
Quality Level
product line
Proligo Reagents
assay
≥99% (31P-NMR)
≥99.0% (reversed phase HPLC)
form
powder
mol wt
801.86 g/mol
impurities
≤0.3% mC2 (reversed phase HPLC, Hydrolysate)
≤0.3% mC3 (reversed phase HPLC, DMT-rC(ac)me)
≤0.3% mC4 (reversed phase HPLC, DMT-rC(ac)me-Ac)
≤0.3% water content (Karl Fischer)
≤0.5% P(III) Impurities 100-169ppm (31P-NMR)
≤0.5% single Impurity (redox titration)
≤1.0% mC1 (redox titration, DMT-rC(ac)me-DMT)
≤3% residual Solvent content
color
white to off-white
suitability
conforms to structure for H-NMR
conforms to structure for LC-MS
compatibility
configured for MerMade
storage temp.
2-8°C
InChI
1S/C42H52N5O9P/c1-28(2)47(29(3)4)57(54-26-12-24-43)56-38-36(55-40(39(38)52-8)46-25-23-37(44-30(5)48)45-41(46)49)27-53-42(31-13-10-9-11-14-31,32-15-19-34(50-6)20-16-32)33-17-21-35(51-7)22-18-33/h9-11,13-23,25,28-29,36,38-40H,12,26-27H2,1-8H3,(H,44,45,48,49)/t36-,38-,39?,40-,57?/m1/s1
Inchi Key
WNWUMIPFLOKTEZ-IXZONTHDSA-N
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General description
- High yield of crude oligonucleotides
- Compatible with DNA synthesis
- Can be employed together with DNA or RNA phosphoramidites in thesame synthesis to produce mixmer oligonucleotides
- Recommended deprotection conditions are 8 hours at 55 °C usingconcentrated ammonia solution, or with AMA (concentrated ammonia/40% aqueous methylamine I/I, v/v) for 10 minutes at 65 °C
- Purification and other downstream processing of fully modified 2′OMethyl RNA oligonucleotides are simpler than in the case of RNA, as nospecial precautions are required to provide protection against nucleolyticdegradation
- Synthesis of 2′O-Methyl RNA oligonucleotides is similar to standard DNA synthesis but requires an elongated coupling time (recommended is 6minutes compared to 90 seconds for DNA monomers)
- 2′O-Methyl RNA phosphoramidites are also available with fast deprotection chemistry
Application
- Diagnostic probes
- Aptamer and ribozyme development
- Mixed 2′O-Methyl-RNA/DNA antisense molecules
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análisis (COA)
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