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B9285
5-Bromo-2′-desoxiuridina
BioUltra, ≥99%
Sinónimos:
5- BrdU, 5-Bromo-1-(2-desoxi-β-D-ribofuranosil)uracilo, BUdR, Desoxirribósido de 5-bromouracilo
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About This Item
Fórmula empírica (notación de Hill):
C9H11BrN2O5
Número de CAS:
Peso molecular:
307.10
Beilstein:
30395
Número CE:
Número MDL:
Código UNSPSC:
41106305
ID de la sustancia en PubChem:
NACRES:
NA.51
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Productos recomendados
origen biológico
synthetic (organic)
Nivel de calidad
Línea del producto
BioUltra
Ensayo
≥99%
Formulario
powder
impurezas
≤0.005% Phosphorus (P)
≤0.1% Insoluble matter
residuo de ign.
≤0.1%
mp
191-194 °C (dec.) (lit.)
solubilidad
NH4OH: 0.1 M at 20 °C, clear, colorless
trazas de catión
Al: ≤0.0005%
Ca: ≤0.01%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.05%
Pb: ≤0.001%
Zn: ≤0.0005%
temp. de almacenamiento
−20°C
cadena SMILES
OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(Br)C(=O)NC2=O
InChI
1S/C9H11BrN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
Clave InChI
WOVKYSAHUYNSMH-RRKCRQDMSA-N
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Descripción general
5′-Bromo-2-deoxyuridine (BrdU) is a carcinogen that may be absorbed by skin or inhalation. BrdU solutions are sensitive to light.[1]
Aplicación
5-Bromo-2′-deoxyuridine has been used:
- to label proliferating cells in pregnant mice in cell proliferation assay[2]
- to study the time course of cell proliferation at various times following ischemia[3], to confirm re-entry of MKI67+ cells in cell cycle to germ cells[4]
- in 5′-Bromo-2′Deoxyuridine (BrdUrd) staining of fibroblasts[5]
Acciones bioquímicas o fisiológicas
Análogo de timidina utilizado como mutágeno en investigación genética. Incorporada de manera selectiva en el ADN celular durante la fase S.
5′-Bromo-2-deoxyuridine (BrdU) staining is predominantly used to observe the multiplication of tumor cells and other tissues in vivo.[6]
5-Bromo-2′-deoxyuridine (5-BrdU) is a thymidine analogue which is incorporated into DNA. 5-BrdU is routinely and extensively used to measure DNA synthesis and to label dividing cells. Consequently 5-BrdU is used to study cell signaling and other processes that induce cell proliferation.
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Muta. 1B - Repr. 2
Código de clase de almacenamiento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Clase de riesgo para el agua (WGK)
WGK 2
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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What is the Department of Transportation shipping information for this product?
1 answer-
Helpful?
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For how long is Product B9285, 5-Bromo-2´-deoxyuridine, stable in solution?
1 answer-
5-Bromo-2´-deoxyuridine is stable in solution for 6 months when stored -20°C.
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What is the shelf life of Product No. B9285 (5-bromo-2´-deoxyuridine)?
1 answer-
Sigma-Aldrich does not assign an expiration date to this product; it is guaranteed for one year from the date of shipment.
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In what solvents is Product B9285, 5-Bromo-2´-deoxyuridine, soluble?
1 answer-
Solubility information for 5-bromo-2´-deoxyuridine can be found on the product information sheet (under Documents, above).
Helpful?
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Can Product B9285, 5-Bromo-2´-deoxyuridine, be injected into animals?
1 answer-
Sigma has not injected animals with solutions of this compound, so we do not have a stepwise procedure for you. However, this application has been reported in the literature. Please see the cited references below, which you may find useful. Several references cite the use of Product No. B9285 in their protocols.1. Yin, X-X, et al., Expression of active caspase-3 in mitotic and postmitotic cells of the rat forebrain. J. Comp. Neurol., 433(1), 4-22 (2001). Injected into mice at 50 mg/kg.2. Dackor, R.T., et al., Hydrops Fetalis, Cardiovascular Defects, and Embryonic Lethality in Mice Lacking the Calcitonin Receptor-Like Receptor Gene. Mol. Cell. Biol., 26(7), 2511-2518 (2006). Injected into mice at 100 mg/kg.3. Farris, S.M., et al., Larval and Pupal Development of the Mushroom Bodies in the Honey Bee, Apis mellifera. J. Comp. Neurol., 414, 97-113 (1999). A 25 mg/mL solution was injected into bee larvae, prepupae, and pupae.4. Gaiano, N., et al., Radial Glial Identity Is Promoted by Notch1 Signaling in the Murine Forebrain. Neuron, 26(2), 395-404 (2000). A 20 mg/mL solution was injected into mice.
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