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Merck
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Key Documents

B8556

Sigma-Aldrich

Hemocyanin from mollusk

buffered aqueous solution

Sinónimos:

Blue Carrier®

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About This Item

Número de CAS:
9013-72-3
MDL number:
MFCD00131280
UNSPSC Code:
12352202
NACRES:
NA.56

biological source

Concholepas sp. (Concholepas concholepas )

Quality Level

200

form

buffered aqueous solution

technique(s)

bioconjugation: suitable

storage temp.

2-8°C

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Application

Blue Carrier is an oxygen-carrying protein isolated from the hemolymph of the mollusk Concholepas concholepas. It is highly immunogenic, useful as a carrier protein for the production of antibodies to small molecules. An example of the protocol is given in reference to production of antibodies to gizzerosine.
Hemocyanin is a carrier protein used in antibody production. It has been used to promote antibody production against haptins and peptides, in therepy for bladder carcinoma, and has a component in vaccines for cancer.

Biochem/physiol Actions

Highly soluble carrier protein used in antibody production

Physical form

100 mg in 0.5 mL of 0.15 M NaCl, 0.1 M sodium phosphate, pH 7.2

Legal Information

Blue Carrier is a registered trademark of Biosonda S.A.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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M I Becker et al.
Hybridoma, 17(4), 373-381 (1998-10-28)
This study is the first report of the development of monoclonal antibodies (MAbs) against gizzerosine (GZ), one of the causative agents of black vomit, a serious poultry disease. Balb/c mice were immunized with different GZ conjugates; the most immunogenic conjugate
Harold Oliva et al.
Hybridoma and hybridomics, 21(5), 365-374 (2002-12-10)
We studied the reactivity of mouse monoclonal antibodies (MAbs) against the hemocyanin from the Chilean marine gastropod Concholepas concholepas (CCH). This protein has been successfully used as a carrier to produce antibodies to haptens and peptides. All MAbs (13) belonging
Enhanced structural stability of Concholepas hemocyanin increases its immunogenicity and maintains its non-specific immunostimulatory effects.
Arancibia S., et al.
European Journal of Immunology (2011)
Bruno Moltedo et al.
The Journal of urology, 176(6 Pt 1), 2690-2695 (2006-11-07)
We determined the antitumor properties of a newly available hemocyanin obtained from the Chilean gastropod Concholepas concholepas (Biosonda Corp., Santiago, Chile) in a syngeneic heterotopic mouse bladder carcinoma model. Since keyhole limpet hemocyanin (Pierce, Rockford, Illinois) is used increasingly in
Anaphylaxis caused by hemocyanin contained in shrimp cephalothorax.
Daiana Guillen et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 113(6), 674-675 (2014-10-14)
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