B6396

2′(3′)-O-(4-Benzoylbenzoyl)adenosine 5′-triphosphate triethylammonium salt

≥93%

• Sinónimos: Benzoylbenzoyl-ATP, Bz-ATP
• Fórmula empírica (notación de Hill): C₂₄H₂₄N₅O₁₅P₃ · xC₆H₁₅N × yH₂O
• Número de CAS: 112898-15-4
• Peso molecular: 715.39 (anhydrous free acid basis)
• Número MDL: MFCD00058547
• Código UNSPSC: 12352202
• ID de la sustancia en PubChem: 329773276
• NACRES: NA.77

Propiedades

• origen biológico: synthetic (organic)
• Nivel de calidad: 200
• Ensayo: ≥93%
• Formulario: powder
• solubilidad: water: 50 mg/mL, clear, colorless to faintly yellow
• temp. de almacenamiento: −20°C
• cadena SMILES: CCN(CC)CC.Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](OC(=O)c4ccc(cc4)C(=O)c5ccccc5)[C@H]3O
• InChI: 1S/C24H24N5O15P3.C6H15N/c25-21-17-22(27-11-26-21)29(12-28-17)23-19(31)20(16(41-23)10-40-46(36,37)44-47(38,39)43-45(33,34)35)42-24(32)15-8-6-14(7-9-15)18(30)13-4-2-1-3-5-13;1-4-7(5-2)6-3/h1-9,11-12,16,19-20,23,31H,10H2,(H,36,37)(H,38,39)(H2,25,26,27)(H2,33,34,35);4-6H2,1-3H3/t16-,19-,20-,23-;/m1./s1
• Clave InChI: HVOVBTNCGADRTH-WBLDMZOZSA-N

Descripción

Descripción general

2′(3′)-O-(4-Benzoylbenzoyl)adenosine 5′-triphosphate is a photoreactive analog of ATP.

Aplicación

2′(3′)-O-(4-Benzoylbenzoyl)adenosine 5′-triphosphate triethylammonium salt has been used as a P2X4 receptor agonist in rat kidney sections, type I diabetes induced rats and astrocyte−neuron coculture. It has also been used as a synthetic ATP analog in isotonic E3 medium.

Useful as a photoaffinity label for proteins and enzymes that bind ATP.

Acciones bioquímicas o fisiológicas

2′(3′)-O-(4-Benzoylbenzoyl)adenosine 5′-triphosphate triethylammonium salt is a selective purinergic receptor (P2X) agonist. It is more potent than ATP at homodimeric P2X7 receptors. It also effectively activates P2X1, P2X2, and P2X3 receptors. Useful as a photoaffinity label for proteins and enzymes that bind ATP.

Selective P2X purinergic agonist. It is more potent than ATP at homodimeric P2X7 receptors.

Otras notas

Mixed isomers

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)