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B1532

Sigma-Aldrich

Resorufin benzyl ether

CYP450 substrate, ≥98% (TLC), powder

Sinónimos:

7-Benzyloxy-3H-phenoxazin-3-one, 7-Benzyloxyresorufin, O7-Benzylresorufin

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About This Item

Fórmula empírica (notación de Hill):
C19H13NO3
Número de CAS:
87687-02-3
Peso molecular:
303.31
MDL number:
MFCD00171613
UNSPSC Code:
12352204
PubChem Substance ID:
24891597
NACRES:
NA.32

product name

Resorufin benzyl ether, CYP450 substrate

Quality Level

200

assay

≥98% (TLC)

form

powder

solubility

chloroform: 9.80-10.20 mg/mL, clear, orange

storage temp.

2-8°C

SMILES string

O=C1C=CC2=Nc3ccc(OCc4ccccc4)cc3OC2=C1

InChI

1S/C19H13NO3/c21-14-6-8-16-18(10-14)23-19-11-15(7-9-17(19)20-16)22-12-13-4-2-1-3-5-13/h1-11H,12H2

InChI key

XNZRYTITWLGTJS-UHFFFAOYSA-N

Substrates

Fluorimetric substrate for cytochrome P450-linked enzymes.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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R D Verschoyle et al.
The Journal of pharmacology and experimental therapeutics, 265(1), 386-391 (1993-04-01)
The O-dealkylation of pentoxyresorufin, a substrate for P450 2B1, was decreased in lung microsomes from rats dosed with O,O,S-trimethylphosphorodithioate, O,O,O-trimethylphosphorothioate, bromophos, fenitrothion, p-xylene and 2,4-dichloro-(6-phenylphonoxy)ethylamine. This activity was decreased by antibodies to P450 2B1 but unaffected by antibodies to P450
Y Q He et al.
Archives of biochemistry and biophysics, 335(1), 152-160 (1996-11-01)
Based on recent studies of single reciprocal mutants of cytochrome P450 2B4 and the highly related P450 2B5 at positions 114, 294, 363, and 367 [G. D. Szklarz, Y. Q. He, K. M. Kedzie, J. R. Halpert, and V. L.
R Perrin et al.
Biochemical pharmacology, 40(9), 2145-2151 (1990-11-01)
The regional and subcellular distributions of rat brain cytochrome P450 and cytochrome P450-dependent activities were examined. Cytochrome P450 was found to be mainly localized in mitochondria in all the six cerebral regions studied. The activities of the isoforms mostly implicated
Benzyloxyresorufin as a specific substrate for the major phenobarbital-inducible dog liver cytochrome P450 (P4502B11).
P A Klekotka et al.
Drug metabolism and disposition: the biological fate of chemicals, 23(12), 1434-1435 (1995-12-01)
R R Meehan et al.
The Biochemical journal, 254(3), 789-797 (1988-09-15)
Cytochrome P-450s are a superfamily of haem-containing proteins involved in the metabolism of foreign compounds, as well as a variety of endogenous molecules. The hepatic levels and function of this diverse group of enzymes are determined by both constitutive and
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