A112000
DMT-dA(tac) Phosphoramidite
Sinónimos:
DMT-dA(tac) amidite
About This Item
Productos recomendados
type
for DNA synthesis
Quality Level
product line
Proligo Reagents
assay
≥98% (31P-NMR)
≥98.0% (reversed phase HPLC)
form
powder
technique(s)
oligo synthesis: suitable
λ
conforms (UV/VIS Identity)
nucleoside profile
base: deoxyadenosine
base protecting group: TAC
2' protecting group: none
5' protecting group: DMT
deprotection: fast
storage temp.
-10 to -25°C
SMILES string
COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)n3cnc4c(NC(=O)COc5ccccc5)ncnc34)(c6ccccc6)c7ccc(OC)cc7
InChI
1S/C48H54N7O8P/c1-33(2)55(34(3)4)64(61-27-13-26-49)63-41-28-44(54-32-52-45-46(50-31-51-47(45)54)53-43(56)30-59-40-16-11-8-12-17-40)62-42(41)29-60-48(35-14-9-7-10-15-35,36-18-22-38(57-5)23-19-36)37-20-24-39(58-6)25-21-37/h7-12,14-25,31-34,41-42,44H,13,27-30H2,1-6H3,(H,50,51,53,56)/t41-,42+,44+,64?/m0/s1
InChI key
INUFZOANRLMUCW-SDNJGBRXSA-N
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General description
Key Features of TAC Chemistry are -
- Deprotection of the TAC group is ultra-fast: complete deprotection in concentrated ammonia occurs within 15 minutes at 55 °C or two hours at room temperature
- Compatible with the AMA deprotection reagent (a mixture of ≥25% ammonia in water with 40% aqueous methylamine I/I, v/v)
- Highly soluble in acetonitrile. No need to add co-solvents such as dimethylformamide or methylene chloride
- Suitable for the synthesis of oligomers with base-labile units e.g., dyes and modifiers, because of less exposure to ammonia and the possibility of room temperature deprotection
- No change is required in the reagents commonly used for DNA synthesis, except that Proligo′s Fast Deprotection Cap A solution is used instead of Cap A solution •
- The application of dA(tac) minimizes depurination and improves the quality of oligonucleotides
Features and Benefits
- The deprotection of oligonucleotide synthesis products with the AMAreagent is ultra-fast: complete deprotection requires 10 minutes at 65 °C
- Side reactions at C-monomers through transamination are eliminated
- Not compatible with some base-labile modified nucleosides
- dC(tac)-phosphoramidite can directly substitute for dC(bz)-phosphoramidite
- No change is required in the reagents commonly used for DNA synthesis.Acetonitrile is used to dissolve phosphoramidite. The standard aceticanhydride capping reagent can be employed.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análisis (COA)
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