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62143

Sigma-Aldrich

Lincomycin hydrochloride

96.0-102.0% (HPLC)

Sinónimos:

Lincocin hydrochloride, Methyl 6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-D-erythro-α-D-galactooctopyranoside hydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C18H34N2O6S · HCl
Número de CAS:
859-18-7
Peso molecular:
443.00
Beilstein:
4171650
Número CE:
212-726-7
Número MDL:
MFCD00083647
Código UNSPSC:
51284507
ID de la sustancia en PubChem:
329759714
NACRES:
NA.85

Nivel de calidad

200

Ensayo

96.0-102.0% (HPLC)

Formulario

powder or crystals

impurezas

≤5% water

color

white to off-white

solubilidad

H2O: 50 mg/mL, clear, colorless to faintly yellow

espectro de actividad antibiótica

Gram-positive bacteria

Modo de acción

protein synthesis | interferes

temp. de almacenamiento

2-8°C

cadena SMILES

Cl.CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@@H](C)O)[C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O

InChI

1S/C18H34N2O6S.ClH/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25);1H/t9-,10-,11+,12-,13+,14-,15-,16-,18-;/m1./s1

Clave InChI

POUMFISTNHIPTI-BOMBIWCESA-N

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Descripción general

Chemical structure: macrolide

Acciones bioquímicas o fisiológicas

Mode of action: Lincomycin inhibits bacterial protein synthesis by forming cross-links within the peptidyl transferase loop region of the 23S rRNA.†

Antimicrobial spectrum: Lincomycin hydrochloride is effective against gram-positive bacteria.

Nota de preparación

This product is soluble in water at 50 mg/mL, yielding a clear, colorless solution.

Otras notas

Keep container tightly closed in a dry and well-ventilated place.

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H315,H319,H335

Clasificaciones de peligro

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
0000405074
0000405074
WXBF4928V
0000395312
0000356917

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S Takebe et al.
Journal of clinical microbiology, 20(5), 869-873 (1984-11-01)
When Ureaplasma urealyticum T-960 was inoculated into normal human urine (10(8) viable cells per ml of urine), a white precipitate formed, with an increase in pH of the infected urine. This precipitate was identified as a mixture of struvite and
J Slots et al.
Antimicrobial agents and chemotherapy, 18(1), 9-12 (1980-07-01)
The agar dilution technique was used for determination of the antibiotic susceptibilities of 57 oral isolates and 2 nonoral isolates of Actinobacillus actinomycetemcomitans. Tetracycline, minocycline, and chloramphenicol inhibited more than 96% of the strains tested at a concentration of less
H Malke et al.
Antimicrobial agents and chemotherapy, 19(1), 91-100 (1981-01-01)
The phenomenon of zonal resistance to lincomycin, which is characteristic of most clinical isolates with lincomycin resistance in Streptococcus pyogenes, has been studied. These strains grow within a defined concentration range of lincomycin (approximately 60 to 200 microgram/ml), or at
Nerissa L Fisher et al.
PloS one, 15(12), e0244252-e0244252 (2020-12-29)
Marine phytoplankton, and in particular diatoms, are responsible for almost half of all primary production on Earth. Diatom species thrive from polar to tropical waters and across light environments that are highly complex to relatively benign, and so have evolved
Kazunori Miyata et al.
Photosynthesis research, 113(1-3), 165-180 (2012-07-17)
When visible light is excess, the photosynthetic machinery is photoinhibited. The extent of net photoinhibition of photosystem II (PSII) is determined by a balance between the rate of photodamage to D1 and some other PSII proteins and the rate of
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