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36799

Sigma-Aldrich

7-(Diethylamino)coumarin-3-carboxylic acid

BioReagent, suitable for fluorescence, ≥98.0% (HPCE)

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About This Item

Fórmula empírica (notación de Hill):
C14H15NO4
Número de CAS:
50995-74-9
Peso molecular:
261.27
Beilstein:
6145963
Número MDL:
MFCD00068721
Código UNSPSC:
12352106
ID de la sustancia en PubChem:
57649663
NACRES:
NA.32

Línea del producto

BioReagent

Nivel de calidad

200

Ensayo

≥98.0% (HPCE)

mp

222-224 °C (dec.) (lit.)

solubilidad

DMF: soluble
DMSO: soluble

fluorescencia

λex 409 nm; λem 473 nm in 0.1 M Tris pH 9.0

idoneidad

suitable for fluorescence

cadena SMILES

CCN(CC)c1ccc2C=C(C(O)=O)C(=O)Oc2c1

InChI

1S/C14H15NO4/c1-3-15(4-2)10-6-5-9-7-11(13(16)17)14(18)19-12(9)8-10/h5-8H,3-4H2,1-2H3,(H,16,17)

Clave InChI

WHCPTFFIERCDSB-UHFFFAOYSA-N

Aplicación

7-(Diethylamino)coumarin-3-carboxylic acid (7-DCCA) may be used to study its photophysical properties in various solvents and solvent mixtures and as a fluorescent label for amine modification and protein conjugation

Envase

Bottomless glass bottle. Contents are inside inserted fused cone.

Otras notas

Fluorescent label for amine modification and protein conjugation

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
BCCM7174
BCCH8789
BCBX5579
BCBS9724V
BCBP8716V

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Keisuke Ikeda et al.
Biochemical and biophysical research communications, 370(3), 525-529 (2008-04-09)
Amyloid beta-protein (Abeta) has been reported to interact with a variety of lipid species, although the thermodynamic driving force remains unclear. We investigated the binding of Abetas labeled with the dye diethylaminocoumarin (DAC-Abetas) to lipid bilayers under various conditions. DAC-Abeta-(1-40)
Aninda Chatterjee et al.
Photochemistry and photobiology, 89(2), 280-293 (2012-09-26)
The photophysical properties of 7-(diethylamino) coumarin-3-carboxylic acid (7-DCCA) were studied in cyclodextrins (α, β, γ,-CDs), different neat solvents and solvent mixtures by using steady state absorption, emission and time-resolved fluorescence spectroscopy. We have observed that with gradual increase in concentration
Tiffany P Gustafson et al.
Chemical communications (Cambridge, England), 49(7), 680-682 (2012-12-12)
Nanothermometers composed from a gold nanorod core, temperature sensitive linker and fluorescent dye are reported. The nanothermometers have low fluorescence due to a self-quenching mechanism at temperatures below 50 °C and become highly fluorescence above 70 °C.
Atsuko Kakio et al.
Biochemistry, 41(23), 7385-7390 (2002-06-05)
GM1 ganglioside-bound amyloid beta-protein (GM1-Abeta), found in brains exhibiting early pathological changes of Alzheimer's disease (AD) plaques, has been suggested to accelerate amyloid fibril formation by acting as a seed. We have previously found using dye-labeled Abeta that Abeta recognizes
Ilaria Catusi et al.
International journal of molecular sciences, 21(22) (2020-11-15)
Maternal uniparental disomy of chromosome 7 is present in 5-10% of patients with Silver-Russell syndrome (SRS), and duplication of 7p including GRB10 (Growth Factor Receptor-Bound Protein 10), an imprinted gene that affects pre-and postnatal growth retardation, has been associated with
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