Y0000563

Amitriptyline hydrochloride

European Pharmacopoeia (EP) Reference Standard

• Sinónimos: AMT
• Fórmula empírica (notación de Hill): C₂₀H₂₃N · HCl
• Número de CAS: 549-18-8
• Peso molecular: 313.86
• Número MDL: MFCD00012537
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329831024
• NACRES: NA.24

Propiedades

• grado: pharmaceutical primary standard
• familia API: amitriptyline
• fabricante / nombre comercial: EDQM
• aplicaciones: pharmaceutical (small molecule)
• Formato: neat
• temp. de almacenamiento: 2-8°C
• cadena SMILES: Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13
• InChI: 1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H
• Clave InChI: KFYRPLNVJVHZGT-UHFFFAOYSA-N
• Información sobre el gen: human ... SLC6A2(6530) , SLC6A4(6532)

Descripción

Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Amitriptyline hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Acciones bioquímicas o fisiológicas

Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with K_is of 100 nM and 14.7 nM, respectively; high in vitro affinity for α₁-adrenoceptors, serotonin and muscarinic acetylcholine receptors.

Tricyclic antidepressant; norepinephrine and serotonin transporter inhibitor; high in vitro affinity for α₁-adrenoceptors, serotonin and muscarinic acetylcholine receptors.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

Información de seguridad

• Pictogramas: GHS06,GHS08,GHS09
• Palabra de señalización: Danger
• Frases de peligro: H301,H319,H361d,H410
• Consejos de prudencia: P201 - P273 - P301 + P310 + P330 - P305 + P351 + P338
• Clasificaciones de peligro: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable