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Merck

Y0000027

Sumatriptan for system suitability

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

Sumatriptan succinate, 3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide succinate, GR-43175

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About This Item

Fórmula empírica (notación de Hill):
C14H21N3O2S · C4H6O4
Número de CAS:
Peso molecular:
413.49
Número MDL:
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
NACRES:
NA.24

grado

pharmaceutical primary standard

familia API

sumatriptan

fabricante / nombre comercial

EDQM

aplicaciones

pharmaceutical (small molecule)

Formato

neat

temp. de almacenamiento

−20°C

cadena SMILES

OC(=O)CCC(O)=O.CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1

InChI

1S/C14H21N3O2S.C4H6O4/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3;5-3(6)1-2-4(7)8/h4-5,8-9,15-16H,6-7,10H2,1-3H3;1-2H2,(H,5,6)(H,7,8)

Clave InChI

PORMUFZNYQJOEI-UHFFFAOYSA-N

Información sobre el gen

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Sumatriptan for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Acciones bioquímicas o fisiológicas

Sumatriptan succinate is a 5-HT1 serotonin receptor agonist.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

Pictogramas

Health hazard

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Aquatic Chronic 3 - Repr. 2

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Certificados de análisis (COA)

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Jeong Ju Seo et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 919-920, 38-42 (2013-02-16)
A sensitive and simple detection method coupling ultra-performance liquid chromatography with tandem mass spectrometry was developed and validated to analyze sumatriptan levels in human plasma. The plasma sample preparations for the analysis were based on liquid-liquid extraction with ethyl acetate
Y Sekino et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 24(12), 1083-e564-1083-e564 (2012-08-14)
Oral sumatriptan administration has been reported to delay gastric emptying after liquid meals. The aim of this study was to determine whether delayed gastric emptying is caused by enhanced gastric accommodation, impaired antral contractions, or both using ultrasonography. Ten healthy
M J Cózar-Bernal et al.
Journal of pharmaceutical and biomedical analysis, 72, 251-260 (2012-10-16)
In this paper, a novel, precise, specific, accurate and rapid reversed-phase high performance liquid chromatographic method was developed, optimized and validated for determining sumatriptan succinate in niosomes with the best chromatographic peak resolution, reduced run time and low cost of
Luigi Alberto Pini et al.
The journal of headache and pain, 13(8), 669-675 (2012-10-12)
In this study, we compared the efficacy and tolerability of the combination of paracetamol 1,000 mg + caffeine 130 mg (PCF) with sumatriptan 50 mg (SUM) in migraine attacks. This was a multi-center randomized double-blind, double-dummy, cross-over controlled trial. The
Yasunari Sakamoto et al.
World journal of gastroenterology, 18(26), 3415-3419 (2012-07-19)
To determine the effect of oral sumatriptan on gastric emptying using a continuous ¹³C breath test (BreathID system). Ten healthy male volunteers participated in this randomized, 2-way crossover study. The subjects fasted overnight and were randomly assigned to receive a

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