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Merck

PHR1796

Supelco

Imipenem

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Imipenem monohydrate, (5R,6S)-6-[(1R)-1-Hydroxyethyl]-3-[[2-[(iminomethyl)amino]ethyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monohydrate, Primaxin monohydrate, Tienam monohydrate

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About This Item

Fórmula empírica (notación de Hill):
C12H17N3O4S · H2O
Número de CAS:
Peso molecular:
317.36
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
NACRES:
NA.24

grado

certified reference material
pharmaceutical secondary standard

Nivel de calidad

Agency

traceable to Ph. Eur. I0090000
traceable to USP 1337809

familia API

imipenem

Formulario

solid

CofA

current certificate can be downloaded

envase

pkg of 200 mg

técnicas

HPLC: suitable
gas chromatography (GC): suitable

aplicaciones

pharmaceutical (small molecule)

temp. de almacenamiento

-10 to -25°C

cadena SMILES

O.C[C@@H](O)[C@@H]1[C@H]2CC(SCCNC=N)=C(N2C1=O)C(O)=O

InChI

1S/C12H17N3O4S.H2O/c1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17;/h5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19);1H2/t6-,7-,9-;/m1./s1

Clave InChI

GSOSVVULSKVSLQ-JJVRHELESA-N

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Descripción general

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Imipenem belongs to the class of carbapenems, a beta-lactam antibiotic, effective against aerobic and anaerobic bacteria. Carbapenems act by inhibiting the peptidoglycan synthesis involved in bacterial cell wall formation, thus causing the death of the target microorganism.

Aplicación

Imipenem may be used as a pharmaceutical reference standard for the quantification of the analyte in biological samples and pharmaceutical formulations by various analytical techniques.

Acciones bioquímicas o fisiológicas

Imipenem monohydrate is a broad spectrum B-lactam antibiotic.
Imipenem monohydrate is a broad spectrum B-lactam antibiotic. It is a member of the carbapenem class of "magic bullet" antibiotics for severe infections.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAC0262 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Producto relacionado

Referencia del producto
Descripción
Precios

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Certificados de análisis (COA)

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Juan R Mella et al.
Shock (Augusta, Ga.), 52(1), 61-66 (2018-08-11)
Substance P (SP) is a neuropeptide that contributes to a proinflammatory state by binding to the neurokinin 1 receptor (NK-1R). Limiting this interaction has been shown to attenuate the acute inflammation. Our hypothesis was that NK-1R activation would contribute to
Determination of imipenem in plasma by high-performance liquid chromatography for pharmacokinetic studies in patients
Garcia-Capdevila L, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 692(1), 127- 132 (1997)
Zainab Edoo et al.
Scientific reports, 7(1), 9136-9136 (2017-08-24)
β-lactam antibiotics act as suicide substrates of transpeptidases responsible for the last cross-linking step of peptidoglycan synthesis in the bacterial cell wall. Nucleophilic attack of the β-lactam carbonyl by the catalytic residue (Ser or Cys) of transpeptidases results in the
Stability-indicating HPLC method development and validation for simultane-ous determination of cilastatin and imipenem in pharmaceutical dosage forms
Kishore MS and Rambabu C
International Journal of Research in Pharmaceutical Sciences, 8(4), 560-567 (2017)
Lipika Singhal et al.
Microbial drug resistance (Larchmont, N.Y.), 24(8), 1082-1088 (2018-02-07)
With the increasing threat of multidrug-resistant organisms, such as Acinetobacter baumannii, the polymyxin class of drugs (colistin and polymyxin B) has become popular in clinical practice. A better understanding of antimicrobial susceptibility testing methods for colistin and polymyxin B is

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