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Merck

PHR1085

Supelco

Homosalate

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

3,3,5-Trimethylcyclohexyl salicylate, 2-Hydroxybenzoic acid 3,3,5-trimethylcyclohexyl ester, Homomenthyl salicylate, Homosalate

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About This Item

Fórmula empírica (notación de Hill):
C16H22O3
Número de CAS:
Peso molecular:
262.34
Beilstein:
2731604
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
NACRES:
NA.24

grado

certified reference material
pharmaceutical secondary standard

Nivel de calidad

Agency

traceable to USP 1311408

familia API

homosalate

CofA

current certificate can be downloaded

técnicas

HPLC: suitable
gas chromatography (GC): suitable

aplicaciones

cleaning products
cosmetics
environmental
food and beverages
personal care
pharmaceutical (small molecule)

Formato

neat

temp. de almacenamiento

2-30°C

cadena SMILES

CC1CC(CC(C)(C)C1)OC(=O)c2ccccc2O

InChI

1S/C16H22O3/c1-11-8-12(10-16(2,3)9-11)19-15(18)13-6-4-5-7-14(13)17/h4-7,11-12,17H,8-10H2,1-3H3

Clave InChI

WSSJONWNBBTCMG-UHFFFAOYSA-N

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Descripción general

Homosalate is a UV filter that protects the skin from the harmful effects of UVB (280-315 nm) and UVA II (315-340 nm) radiations. It is widely utilized in make-up, sunscreen and topical formulations.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicación

Homosalate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography methods.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAC3174 in the slot below. This is an example certificate only and may not be the lot that you receive.

Producto relacionado

Referencia del producto
Descripción
Precios

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

339.4 °F - closed cup

Punto de inflamabilidad (°C)

170.8 °C - closed cup


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Supercritical fluid extraction and high performance liquid chromatography determination of homosalate in lipsticks
Salvador A, et al.
Chromatographia, 54(11-12), 795-797 (2001)
Homosalate
USP42-NF37: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 37(2), 2163-2163 (2013)
E Chatelain et al.
Skin pharmacology and applied skin physiology, 16(1), 28-35 (2003-02-05)
To gain information about efficacy and safety of sunscreens, we compared the skin penetration of ultraviolet (UV) filters from two vehicles, i.e. an oil-in-water (O/W) emulsion gel and petrolatum jelly both in vitro and in vivo, as well as the
Comments on "In vitro and in vivo estrogenicity of UV screens".
H M Bolt et al.
Environmental health perspectives, 109(8), A358-A361 (2001-09-21)
G F Gerberick et al.
Contact dermatitis, 20(4), 251-259 (1989-04-01)
The potential of 3 sunscreens (p-aminobenzoic acid, 4-isopropyldibenzoylmethane and homosalate) and 2 known human photoallergens (musk ambrette and tetrachlorosalicylanilide) to cause photoallergy, phototoxicity, and/or contact sensitization was determined using a guinea pig photoallergy model, as previously described by Harber and

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