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Merck

M8640

Sigma-Aldrich

1-Methoxy-5-methylphenazinium methyl sulfate

≥95% purity , powder

Sinónimos:

1-Methoxyphenazine methosulfate

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About This Item

Fórmula empírica (notación de Hill):
C15H16N2O5S
Número de CAS:
Peso molecular:
336.36
EC Number:
MDL number:
UNSPSC Code:
12171500
PubChem Substance ID:
NACRES:
NA.47
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Nombre del producto

1-Methoxy-5-methylphenazinium methyl sulfate, ≥95%

Quality Level

assay

≥95%

form

powder

composition

Nitrogen: ≥ 7.9%

technique(s)

titration: suitable

color

red to brown

solubility

H2O: 1 mg/mL, clear, red

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

COS([O-])(=O)=O.COc1cccc2[n+](C)c3ccccc3nc12

InChI

1S/C14H13N2O.CH4O4S/c1-16-11-7-4-3-6-10(11)15-14-12(16)8-5-9-13(14)17-2;1-5-6(2,3)4/h3-9H,1-2H3;1H3,(H,2,3,4)/q+1;/p-1

InChI key

MASUWVVNWALEEM-UHFFFAOYSA-M

General description

1-Methoxy-5-methylphenazinium methyl sulfate (MPMS) is a photochemically stable electron-transport mediator between NAD(P)H and tetrazolium dyes. The reduced form of MPMS converts tetrazolium salt to purple precipitate formazan.[1]It is a very stable and non-enzymic electron carrier that mediates electron transfer by dehydrogenases in vitro to various electron acceptors such as tetrazolium dyes or the electrode of an enzymic electric cell.

Application

1-Methoxy-5-methylphenazinium methyl sulfate has been used as a component of buffers or solutions for the assay of lactate dehydrogenase[2] and muscle succinate dehydrogenase.[3]

pictograms

Health hazardExclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Muta. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2

target_organs

Nervous system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


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Patries M Herst et al.
Biochimica et biophysica acta, 1767(2), 170-177 (2007-02-03)
Oxygen consumption for bioenergetic purposes has long been thought to be the prerogative of mitochondria. Nevertheless, mitochondrial gene knockout (rho(0)) cells that are defective in mitochondrial respiration require oxygen for growth and consume oxygen at the cell surface via trans-plasma
S Nakamura et al.
Clinica chimica acta; international journal of clinical chemistry, 101(2-3), 321-326 (1980-02-28)
1-Methoxy-5-methylphenazinium methyl sulfate (1-methoxyPMS) is a photochemically stable electron mediator between NAD(P)H and tetrazolium dyes. We have examined the efficiency of 1-methoxyPMS as an electron mediator in the assay of human lactate dehydrogenase (LDH, EC 1.1.1.27) and the activity staining
An optimized lactate dehydrogenase release assay for screening of drug candidates in neuroscience.
Kaja S, et. al.
Journal of Pharmacological and Toxicological Methods, 73, 1-1 (2015)
Early life exposure to chronic intermittent hypoxia causes upper airway dilator muscle weakness, which persists into young adulthood.
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Development of chemotherapeutic/preventive drugs that selectively kill cancer - the Holy Grail of cancer research - is a major challenge. A particular difficulty arises when chemotherapeutics and radiation are found to be rather ineffective against quiescent cancer cells in solid

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