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Key Documents

I0775020

Isosorbide 2-nitrate

European Pharmacopoeia (EP) Reference Standard

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About This Item

Fórmula empírica (notación de Hill):
C6H9NO6
Número de CAS:
16106-20-0
Peso molecular:
191.14
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

isosorbide

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

InChI

1S/C6H9NO6/c8-3-1-11-6-4(13-7(9)10)2-12-5(3)6/h3-6,8H,1-2H2/t3-,4+,5-,6-/m1/s1

InChI key

YWXYYJSYQOXTPL-JGWLITMVSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Isosorbide 2-nitrate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Referencia del producto
Descripción
Precios

1352008

Isosorbide, United States Pharmacopeia (USP) Reference Standard

1353000

Diluted isosorbide dinitrate (25% mixture with lactose), United States Pharmacopeia (USP) Reference Standard

I0775000

Isosorbide dinitrate, European Pharmacopoeia (EP) Reference Standard

I0775010

Isosorbide mononitrate, European Pharmacopoeia (EP) Reference Standard

PHR1486

Isosorbide Solution, Pharmaceutical Secondary Standard; Certified Reference Material

1353102

Diluted Isosorbide Mononitrate, United States Pharmacopeia (USP) Reference Standard

1353113

Diluted Isosorbide Mononitrate Related Compound A, United States Pharmacopeia (USP) Reference Standard

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

Lo sentimos, en este momento no disponemos de COAs para este producto en línea.

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M G Bogaert
Cardiovascular drugs and therapy, 8(5), 693-699 (1994-10-01)
The pharmacokinetics of organic nitrates are discussed with emphasis on the possible clinical relevance. For glyceryl trinitrate, the measurement of plasma concentrations is very difficult. Its pharmacokinetics are unusual, with a very rapid disappearance from plasma, and large intraindividual and
Y Gomita et al.
The Journal of pharmacy and pharmacology, 43(11), 811-812 (1991-11-01)
Rats dosed orally with isosorbide dinitrate (1 mg kg-1) were exposed to smoke from standard and nicotine-reduced cigarettes for 8 min using a smoking machine. Plasma concentrations of isosorbide dinitrate and 5-isosorbide mononitrate, one of its major metabolites were approximately
Riccardo Raddino et al.
Journal of cardiovascular medicine (Hagerstown, Md.), 11(7), 486-492 (2010-04-24)
Nitrates are used in the treatment of coronary heart disease and heart failure. The major drawback of their therapeutic use is the rapid development of tolerance. To investigate the effect of different nitrates on isolated rabbit hearts and aortic strips
T B Tzeng et al.
Journal of chromatography, 571(1-2), 109-120 (1991-11-15)
A specific, sensitive and precise capillary gas chromatographic method using electron-capture detection was developed for the determination of four isomeric vasodilating organic mononitrates, viz. L-isoidide mononitrate (L-IIMN), isosorbide-2-mononitrate (IS-2-MN), isomannide mononitrate (IMMN) and isosorbide-5-mononitrate (IS-5-MN), in rat plasma. With a
R De Caterina et al.
American heart journal, 119(4), 855-862 (1990-04-01)
Isosorbide monitrates (IS-2-MN and IS-5-MN), hepatic metabolites of isosorbide dinitrate, inhibit platelet function in vitro very differently, with IS-2-MN being much more potent than IS-5-MN. To assess their antiplatelet properties in vivo and to compare time and dosage requirements, we
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