91095

Trichloroacetyl isocyanate

purum, ≥97.0% (GC)

• Sinónimos: 2,2,2-Trichloroacetyl isocyanate, alpha,alpha,alpha-Trichloroacetyl isocyanate
• Fórmula lineal: Cl₃CCONCO
• Número de CAS: 3019-71-4
• Peso molecular: 188.40
• Beilstein/REAXYS Number: 971201
• EC Number: 221-165-7
• MDL number: MFCD00002033
• UNSPSC Code: 12352100
• PubChem Substance ID: 329769998
• NACRES: NA.22

Propiedades

• grade: purum
• Quality Level: 100
• assay: ≥97.0% (GC)
• form: liquid
• refractive index: n20/D 1.480 (lit.); n20/D 1.480
• bp: 80-85 °C/20 mmHg (lit.)
• density: 1.581 g/mL at 25 °C (lit.)
• functional group: amine; chloro; isocyanate
• storage temp.: 2-8°C
• SMILES string: ClC(Cl)(Cl)C(=O)N=C=O
• InChI: 1S/C3Cl3NO2/c4-3(5,6)2(9)7-1-8
• InChI key: GRNOZCCBOFGDCL-UHFFFAOYSA-N

Descripción

General description

Trichloroacetyl isocyanate (TAI) is a versatile building block in organic synthesis. It is also used as an in situ derivatizing reagent for the characterization of phenols, alcohols, and amines.

Application

• One-pot synthesis of 2-acylaminobenzimidazoles: A study on the synthesis of 2-acylaminobenzimidazoles via a reaction between trichloroacetyl isocyanate and 1,2-phenylenediamine derivatives (Shajari et al., 2018).


• Cabamothioate compounds: Research on the synthesis of S-aryl (trichloroacetyl) carbamothioate from a reaction of 2-naphthalenethiol or thiophenol derivatives and trichloroacetyl isocyanate (Shajari et al., 2021).


• Chiral calyx[4]arenes: Diastereoselective synthesis of inherently chiral calyx[4]arenes via reaction of trichloroacetyl isocyanate with 1,3-dihydroxy calixarene (Boyko et al., 2016).

Other Notes

Derivatizing reagent for the structural assignment to hydroxy compounds by NMR; Used in negative ion chemical ionization mass spectrometry

Información de seguridad

• pictograms: GHS06,GHS08,GHS05
• signalword: Danger
• hcodes: H311 + H331,H314,H317,H334
• pcodes: P261 - P271 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3
• flash_point_f: 150.8 °F - closed cup
• flash_point_c: 66 °C - closed cup
• ppe: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter