52619

Hexamethyldisilazane

for GC derivatization, LiChropur^™, ≥99.0% (GC)

• Sinónimos: HMDS
• Fórmula lineal: (CH₃)₃SiNHSi(CH₃)₃
• Número de CAS: 999-97-3
• Peso molecular: 161.39
• Beilstein/REAXYS Number: 635752
• EC Number: 213-668-5
• MDL number: MFCD00008259
• UNSPSC Code: 12000000
• PubChem Substance ID: 329757861
• NACRES: NA.22

Propiedades

• grade: for GC derivatization
• Quality Level: 100
• assay: ≥99.0% (GC)
• form: liquid
• quality: LiChropur^™
• reaction suitability: reagent type: derivatization reagent; reaction type: Silylations
• technique(s): gas chromatography (GC): suitable
• refractive index: n20/D 1.407 (lit.); n20/D 1.408
• bp: 125 °C (lit.)
• SMILES string: C[Si](C)(C)N[Si](C)(C)C
• InChI: 1S/C6H19NSi2/c1-8(2,3)7-9(4,5)6/h7H,1-6H3
• InChI key: FFUAGWLWBBFQJT-UHFFFAOYSA-N

Descripción

General description

Hexamethyldisilazane (HMDS) is a commercially available, silylating agent,[1][2] which is used as an alternative for the preparation of silyl ethers from hydroxyl compounds.[2]

Application

Learn more in the Product Information

Hexamethyldisilazane is suitable for the derivatization of alcohols, U-aminobutyric acid, pesticidal carbamates and urea, 3,4-Dihydroxyphenylglycol, 4-hydroxycoumarins, hydroxyfatty acids, n-hydroxy-2-fluorenylacetamide, kerb cycle acid, malonaldehyde, monoglycerides, phenylpyruvic acid, shikimic acid, unsaturated fatty acid esters (or methyl esters), and related compounds.

It may be used as a derivatizing reagent for the analysis of bioamines and their acidic metabolites,[3] phenol, hydroquinone and catechol[4] in urine samples, mixtures of free fatty acids and metal soaps in paint samples[5] using gas chromatography/mass spectrometry (GC/MS).

Suitable for the derivatization of alcohols, Υ-aminobutyric acid, pesticidal carbamates and urea, 3,4-Dihydroxyphenylglycol, 4-hydroxycoumarins, hydroxyfatty acids, n-hydroxy-2-fluorenylacetamide, kerb cycle acid, malonaldehyde, monoglycerides, phenylpyruvic acid, shikimic acid, unsaturated fatty acid esters (or methyl esters), and related compounds.

Features and Benefits

• HMDS is inexpensive and has a relatively low boiling point (124-127 °C).        
• It can be used without solvent but its silylating power can be increased by various (mostly acidic) catalysts.        
• The only reaction byproduct, ammonia, can leave the reaction mixture as the reaction goes to completion.

Other Notes

Importante agente sililante[6][7]

Reagent for 2-hydroxypyrimidine, polytrimethylsilyloxy, trimethylsilyl and trimethylsilyl oximes.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• pictograms: GHS02,GHS06
• signalword: Danger
• hcodes: H225,H302 + H332,H311,H412
• pcodes: P210 - P273 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Flam. Liq. 2
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 2
• flash_point_f: 52.5 °F - closed cup
• flash_point_c: 11.4 °C - closed cup
• ppe: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter