10102105001
Roche
Adenosine Deaminase (ADA)
from calf intestine
Sinónimos:
ADA
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About This Item
Productos recomendados
origen biológico
bovine (calf) intestine
Nivel de calidad
Formulario
solution
actividad específica
~200 units/mg protein (At 25 °C with adenosine as the substrate.)
mol peso
230-440 kDa (high)
30-47 kDa (low )
envase
pkg of 2 mL (10 mg)
fabricante / nombre comercial
Roche
pH óptimo
7.0-7.4
Condiciones de envío
wet ice
temp. de almacenamiento
2-8°C
Categorías relacionadas
Descripción general
Adenosine Deaminase (ADA) is present majorly in the proximal small intestine and the duodenum. It is also called Adenosine aminohydrolase. It is a zinc metalloenzyme and exists as a high (230−440 kDa) and low molecular weight (30−47 kDa) isoforms.
Adenosine deaminase (ADA) is a zinc metalloenzyme.
Aplicación
Adenosine Deaminase (ADA) has been used as a component of macrophage- serum-free media (SFM) to treat macrophages.
Adenosine deaminase has been used to pre-treat primary Kupffer cells.
Acciones bioquímicas o fisiológicas
Adenosine Deaminase (ADA) catalyzes the deamination of adenosine analogs to the corresponding inosine analogs. It is present in high levels in colorectal cancer and is a potential marker in tuberculous pleuriti. ADA deficiency affects T-and B-lymphocytes resulting in severe combined immunodeficiency (SCID) leading to lymphocytopenia.
Adenosine deaminase (ADA) is involved in the deamination of adenosine to inosine and 2′ deoxyadenosine to 2′-deoxyinosine.
Calidad
Contaminants: <0.01% alkaline phosphatase, AMP-deaminase, guanase, and nucleoside phosphorylase each
Forma física
Solution in 50% glycerol (v/v), 10 mM potassium phosphate, pH approximately 6
Nota de preparación
Storage conditions (working solution): ADA (all preparations) may be dialyzed, without loss of activity, at 2 to 8 °C against 20 mM phosphate buffer, pH 7. The dialyzed preparation is stable at -15 to -25 °C.
Otras notas
For life science research only. Not for use in diagnostic procedures.
Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
does not flash
Punto de inflamabilidad (°C)
does not flash
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