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MAB2259Z

Sigma-Aldrich

Anti-Integrin β1 Antibody, activated, clone B44, azide free

clone B44, Chemicon®, from mouse

Sinónimos:

Ligand-inducedBindingSite, LIBS, CLIBS, MAB2259

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

B44, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

cell culture | mammalian: suitable
flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_002292.3

UniProt accession no.

P55268

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... ITGB1(3688)

Specificity

Detects a cation- and ligand-induced binding site (LIBS) of integrin beta 1, which has been used in some systems as a reporter of integrin functionality.

Application

Immunoprecipitation of detergent-solubilized (1 integrins: 2-4 μg/IP

Western blot: 10-15 μg/mL

Flow Cytometry: 10-15 μg/mL

Immunohistochemistry

Stimulation of (1-mediated adhesion: 10-20 μg/mL.

Optimal working dilutions must be determined by end user.
This Anti-Integrin β1 Antibody, activated, clone B44, azide free is validated for use in FC, IH, IP, FUNC, CULT, WB for the detection of Integrin β1.

Target description

88 kDa

Physical form

Format: Purified
Purified immunoglobulin. Liquid PBS, containing no preservatives.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Descripción
Precios

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Wan-Chun Chen et al.
American journal of physiology. Renal physiology, 307(6), F695-F707 (2014-07-25)
To explore whether matrix stiffness affects cell differentiation, proliferation, and transforming growth factor (TGF)-β1-induced epithelial-mesenchymal transition (EMT) in primary cultures of mouse proximal tubular epithelial cells (mPTECs), we used a soft matrix made from monomeric collagen type I-coated polyacrylamide gel
M Levite et al.
European journal of immunology, 31(12), 3504-3512 (2001-12-18)
Dopamine by itself has not up to now been reported to activate T cell function. We show here that dopamine interacts directly with dopaminergic receptors on normal human T cells and triggers beta1 integrin-mediated T cell adhesion to a major
Cheng-Te Hsiao et al.
Oncotarget, 8(41), 70653-70668 (2017-10-21)
Directed cell migration is an important step in effective wound healing and requires the dynamic control of the formation of cell-extracellular matrix interactions. Plasma fibronectin is an extracellular matrix glycoprotein present in blood plasma that plays crucial roles in modulating
Izabela Staniszewska et al.
Journal of cell science, 121(Pt 4), 504-513 (2008-01-31)
The integrin alpha9beta1 is a multifunctional receptor that interacts with a variety of ligands including vascular cell adhesion molecule 1, tenascin C and osteopontin. We found that this integrin is a receptor for nerve growth factor (NGF) and two other
Tommy Hui et al.
Matrix biology : journal of the International Society for Matrix Biology, 41, 19-25 (2014-12-03)
Osteopontin (OPN) is a ligand for the α4ß1 integrin, but the physiological importance of this binding is not well understood. Here, we have assessed the effect of post-translational modifications on OPN binding to the α4 integrin on cultured human leukocyte
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