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Key Documents

AG938

Sigma-Aldrich

Synuclein, α, recombinant human

Sinónimos:

α-Synuclein protein, Alpha Synuclein

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About This Item

UNSPSC Code:
12352200
eCl@ss:
32160405
NACRES:
NA.41

biological source

human

Quality Level

assay

>95% (gel scan and mass spectrometry)

form

solid

shelf life

12 mo.

manufacturer/tradename

Chemicon®

solubility

water: slightly soluble

suitability

suitable for molecular biology

NCBI accession no.

UniProt accession no.

Gene Information

human ... SNCA(6622)

General description

Research area: Neuroscience

α-Synuclein, a member of the synuclein family of proteins that localize to presynaptic terminals under physiological conditions. It is comprised of three primary regions: an amino terminus containing apolipoprotein lipid-binding motifs, which are anticipated to form amphiphilic helices. The central region, known as non-Aβ component (NAC) containing a hydrophobic domain that gives β-sheet potential, and the carboxyl terminus, characterized by a high negative charge and remains unstructured. Under physiological conditions, members of the synuclein family, including α-synuclein, are predominantly neuronal proteins.

Application

Synuclein, α, recombinant human has been used:
  • for preparation of α-synuclein fibrils to access the SAR228810 antibody against the risk of amyloid-related imaging abnormalities (ARIA).
  • to study the formation of isoasparate protein damage responsible to trigger familial Parkionsonian phenotypes.
  • to study its interaction with iron and copper, in order to understand their role in proteinopathies.

Biochem/physiol Actions

Synuclein, α is the principal component of Lewy bodies and a pathological hallmark of synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). The deposition of αS aggregates is a defining characteristic of all these diseases.

Physical form

Lyophilized from TBS. Resuspend in water at a concentration of 1 mg/mL.

Storage and Stability

Maintain lyophilized material at -20ºC for up to 12 months after date of receipt. After reconstitution maintain at -20ºC to -70ºC for up to 2 weeks in undiluted aliquots. Avoid freeze/thaw cycles to avoid aggregation.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Molecular ageing of alpha- and Beta-synucleins: protein damage and repair mechanisms
Vigneswara V, et al.
PLoS ONE, 8(4), e61442-e61442 (2013)
SAR228810: an antibody for protofibrillar amyloid ? peptide designed to reduce the risk of amyloid-related imaging abnormalities (ARIA)
Pradier L, et al.
Alzheimer's Research & Therapy, 10(1), 117-117 (2018)
?-Synuclein in Parkinson's Disease
Stefanis L
Cold Spring Harbor Perspectives in Medicine, 2(2), a009399-a009399 (2012)
The many faces of ?-synuclein: from structure and toxicity to therapeutic target
Lashuel HA, et al.
Nature Reviews. Neuroscience, 14, 38-48 (2013)
Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies
Lermyte F, et al.
Cells, 8(10), 1231-1231 (2019)

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