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Key Documents

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AB1570

Sigma-Aldrich

Anti-GABA Transporter-1 Antibody, CT (a.a. 588-599)

Chemicon®, from rabbit

Sinónimos:

GAT-1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

monkey, feline, rat, human, mouse, rabbit

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable

suitability

not suitable for Western blot

NCBI accession no.

NM_003042.2

UniProt accession no.

P30531

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... SLC6A1(6529)

Specificity

GABA Transporter-1 (GAT-1), C-terminus. No cross-reactivity to the C-termini of other transmitter transporters detected.

Immunogen

Epitope: C-terminus (a.a. 588-599)
Rat GAT-1, C-terminus (aa 588-599)

Application

Anti-GABA Transporter-1 Antibody, C-terminus (a.a. 588-599) is an antibody against GABA Transporter-1 for use in IH.
Immunohistochemistry: 1:500-1:750 on 4% paraformaldehyde fixed or 4% paraformaldehyde and 0.2% glutaraldehyde fixed tissue. It is recommended that the antibody be diluted in PBS containing 10% normal goat serum and 0.5% Triton X-100. AB1570 has been used for both light and electron microscopic studies of rat retina, cortex and hippocampus.

Note: AB1570 is not recommended for Western blot use. See AB1570W.

Optimal working dilutions must be determined by the end user.

Physical form

Affinity purified antibody. Lyophilized from in 0.1 M PBS with 1% BSA and 0.1% sodium azide. Reconstitute with 100 μL of sterile distilled water.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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GHS07

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Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Chronic 3

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Constantino Sotelo
The Journal of comparative neurology, 506(2), 240-262 (2007-11-21)
The acquisition of the dynamic balance between excitation and inhibition in developing Purkinje cells, necessary for their proper function, is analyzed. Newborn (P0) mouse cerebellum contains glutamatergic (VGLUT2-IR) and gamma-aminobutyric acid (GABA)-ergic (VIAAT-IR) axons. The former prevail and belong to
Pericellular innervation of neurons expressing abnormally hyperphosphorylated tau in the hippocampal formation of Alzheimer's disease patients.
Blazquez-Llorca, L; Garcia-Marin, V; Defelipe, J
Frontiers in Neuroanatomy null
Muhamed N H Eeza et al.
Journal of Alzheimer's disease : JAD, 81(2), 797-808 (2021-04-13)
Circadian rhythm disturbance is commonly observed in Alzheimer's disease (AD). In mammals, these rhythms are orchestrated by the superchiasmatic nucleus (SCN). Our previous study in the Tg2576 AD mouse model suggests that inflammatory responses, most likely manifested by low GABA
Lu Pu et al.
Evidence-based complementary and alternative medicine : eCAM, 2012, 818451-818451 (2013-02-01)
Analgesia is a well-documented effect of acupuncture. A critical role in pain sensation plays the nervous system, including the GABAergic system and opioid receptor (OR) activation. Here we investigated regulation of GABA transporter GAT1 by δOR in rats and in
Xinjun Wang et al.
The Journal of physiology, 592(19), 4257-4276 (2014-08-03)
GABAergic terminals of chandelier cells exclusively innervate the axon initial segment (AIS) of excitatory neurons. Although the anatomy of these synapses has been well-studied in several brain areas, relatively little is known about their physiological properties. Using vesicular γ-aminobutyric acid
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