673000

Vacuolin-1

≥95% (HPLC), solid, lysosome inhibitor, Calbiochem^®

• Sinónimos: Vacuolin-1
• Fórmula empírica (notación de Hill): C₂₆H₂₄IN₇O
• Número de CAS: 351986-85-1
• Peso molecular: 577.42
• Número MDL: MFCD00321410
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nombre del producto: Vacuolin-1, A cell-permeable triazine based compound that inhibits Ca²⁺-dependent fusion of lysosomes with the plasma membrane and the release of lysosomal content, without affecting enlargeosomes or other membrane-bound organelles.
• Nivel de calidad: 100
• Ensayo: ≥95% (HPLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: white
• solubilidad: DMSO: 25 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C
• cadena SMILES: Ic1cc(ccc1)\C=N\Nc2nc(nc(n2)N(c5ccccc5)c4ccccc4)N3CCOCC3
• InChI: 1S/C26H24IN7O/c27-21-9-7-8-20(18-21)19-28-32-24-29-25(33-14-16-35-17-15-33)31-26(30-24)34(22-10-3-1-4-11-22)23-12-5-2-6-13-23/h1-13,18-19H,14-17H2,(H,29,30,31,32)/b28-19+
• Clave InChI: JMEJTSRAQUFNOP-TURZUDJPSA-N

Descripción

Descripción general

A cell-permeable triazine based compound that inhibits Ca²⁺-dependent fusion of lysosomes with the plasma membrane and the release of lysosomal content, without affecting enlargeosomes or other membrane-bound organelles. It does not disturb the organization of the actin or tubulin cytoskeletal network, nor does it interfere with membrane traffic along the constitutive pathway from the ER to the plasma membrane.

A cell-permeable triazine-based compound that inhibits Ca²⁺-dependent exocytosis of lysosomes induced by ionomycin or plasma membrane wounding. Does not affect the resealing process and the exocytosis of enlargeosomes. It also does not disturb the organization of the actin or tubulin cytoskeletal network or interfere with membrane traffic along the constitutive pathway from the ER to the plasma membrane.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
Ca2+-dependent fusion of lysosomes with the plasma membrane

Product does not compete with ATP.

Reversible: no

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Otras notas

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable