539610

PKC_ζ/ι Pseudosubstrate Inhibitor

The PKC_ζ/ι Pseudosubstrate Inhibitor controls the biological activity of PKC_ζ/ι. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinónimos: PKC_ζ/ι Pseudosubstrate Inhibitor, SIYRRGARRWRKL, Protein Kinase C _ζ/ι Pseudosubstrate Inhibitor, SIYRRGARRWRKL, Protein Kinase C_ζ/ι Pseudosubstrate Inhibitor
• Fórmula empírica (notación de Hill): C₇₆H₁₂₈N₃₀O₁₆
• Peso molecular: 1718.02
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: lyophilized
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• solubility: glacial acetic acid: 2 mg/mL; water: 2 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Descripción

General description

A selective, reversible, and substrate competitive inhibitor of protein kinase C_ζ and protein kinase C_ι (PKC_ζ/ι) isozymes.

Non-cell-permeable protein kinase C_ζ and protein kinase C_ι pseudosubstrate sequence peptide that can be used as a selective, reversible, and substrate competitive inhibitor PKC_ζ/ι in in vitro kinase assays.

Biochem/physiol Actions

Cell permeable: no

Primary Target
PKCζ

Product does not compete with ATP.

Reversible: yes

Warning

Toxicity: Standard Handling (A)

Sequence

H-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu-OH

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Sajan, M.P., et al. 1999. J. Biol. Chem.274, 30495.
Laudanna, C., et al. 1998. J. Biol. Chem.273, 30306.
Standaert, M.L., et al. 1997. J. Biol. Chem.272, 30075.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable