454202

8-Methoxymethyl-3-isobutyl-1-methylxanthine

A cell-permeable selective inhibitor of Ca²⁺-calmodulin-dependent phosphodiesterase (PDE I; IC₅₀ = 4 µM).

• Sinónimos: 8-Methoxymethyl-3-isobutyl-1-methylxanthine, 8-Methoxymethyl-IBMX
• Fórmula empírica (notación de Hill): C₁₂H₁₈N₄O₃
• Número de CAS: 78033-08-6
• Peso molecular: 266.30
• MDL number: MFCD00211081
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥98% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: ethanol: 2 mg/mL; DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• InChI: 1S/C12H18N4O3/c1-7(2)5-16-10-9(11(17)15(3)12(16)18)13-8(14-10)6-19-4/h7H,5-6H2,1-4H3,(H,13,14)
• InChI key: NBLBCGUCPBXKOV-UHFFFAOYSA-N

Descripción

General description

A cell-permeable selective inhibitor of Ca²⁺-calmodulin-dependent phosphodiesterase (PDE I; IC₅₀ = 4 µM).

A cell-permeable, selective inhibitor of Ca²⁺-calmodulin-dependent phosphodiesterase (PDE I, IC₅₀ = 4 µM).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
PDE 1

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 4 µM against Ca2+-calmodulin-dependent phosphodiesterase (PDE I)

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Jackson, E.K., et al. 1997. J. Cardiovasc. Pharmacol. 30, 798.
Ahn, H.S., et al. 1989. Biochem. Pharmacol.38, 3331.
Han, P., et al. 1989. J. Biol. Chem.274, 22337.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable