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Documentos clave

407709

Sigma-Aldrich

Insulin, Zinc, Human, Recombinant, P. pastoris

Sinónimos:

Insulin, Zinc, Human, Recombinant, P. pastoris

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About This Item

Número de CAS:
Número MDL:
Código UNSPSC:
12352202
NACRES:
NA.77
origen biológico:
yeast (Pichia pastoris)
Formulario:
solid
Ensayo:
≥95—105%
En este momento no podemos mostrarle ni los precios ni la disponibilidad

origen biológico

yeast (Pichia pastoris)

Nivel de calidad

descripción

Merck USA index - 14, 4980

esterilidad

non-sterile

Ensayo

≥95—105%

Formulario

solid

actividad específica

≥25 IU/mg (dry basis)

fabricante / nombre comercial

Calbiochem®

condiciones de almacenamiento

OK to freeze

impurezas

<10 EU/mg Endotoxin (EU/mg protein)

color

white to off-white

solubilidad

0.01 M HCl: soluble

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

Clave InChI

PBGKTOXHQIOBKM-FHFVDXKLSA-N

Descripción general

Recombinant, human insulin (zinc) expressed in P. pastoris. Peptide anabolic hormone produced by pancreatic β-cells. Increases the synthesis of protein, fat, glycogen, and substrate oxidation in mitochondria. Interacts with membrane insulin receptor to cause its biological actions.

Advertencia

Toxicity: Standard Handling (A)

Nota de preparación

Insulin is practically insoluble from pH 4.5-7.0.

Reconstitución

Following reconstitution store in the refrigerator (4°C). Stock solutions are stable for up to 6 weeks at 4°C.

Otras notas

Mohan, C., et al. 1989. Curr. Topics Cell. Reg.30, 105.
Johnson, I.S. 1983. Science219, 632.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

nwg


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Mohan Sreelekshmi et al.
Journal of biochemical and molecular toxicology, 35(6), 1-8 (2021-03-03)
Glucokinase (GK), a key regulator of hepatic glucose metabolism in the liver and glucose sensor and mediator in the secretion of insulin in the pancreas, is not studied in detail for its therapeutic application in diabetes. Herein, we study the
Medha Sharma et al.
Cell communication and signaling : CCS, 20(1), 179-179 (2022-11-16)
The aim of the present study was to determine the role of individual PHLPP isoforms in insulin signaling and insulin resistance in neuronal cells. PHLPP isoforms were either silenced or overexpressed individually, and the effects were observed on individual Akt
Yamini Yadav et al.
The FEBS journal, 289(23), 7561-7581 (2022-07-11)
PP2Cα is one of the newly identified isoforms of metal-dependent protein phosphatases (PPM). The role of this phosphatase in neuronal insulin signalling is completely unknown. In the present study, we show insulin-mediated rapid upregulation of a protein of the insulin
Kapil Manglani et al.
Cell biology international, 46(3), 488-497 (2021-12-06)
Role of CDK5 and its inhibition in various neuronal processes and functions are well established. However, role of CDK5 and its inhibition in neuronal insulin-signaling and-resistance is not yet explored. In the present study, we investigated the effect of CDK5
Kerrie A Morrison et al.
Scientific reports, 12(1), 3532-3532 (2022-03-05)
Extraction of integral membrane proteins with poly(styrene-co-maleic acid) provides a promising alternative to detergent extraction. A major advantage of extraction using copolymers rather than detergent is the retention of the lipid bilayer around the proteins. Here we report the first

Questions

  1. I want know about the MW and purity of this product

    1 answer
    1. The molecular weight of Product 407709 Insulin, Zinc, Human, Recombinant, is 5807 Da. Purity is 99.2 % pure by HPLC, < 10.0 EnU/mg, and Potency of 28.5 IU/mg.

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