309795

DIDS disodium salt

≥85% (HPLC), solid, anion transport inhibitor, Calbiochem^®

• Sinónimos: DIDS, Disodium Salt, 4,4ʹ-Diisothiocyanostilbene-2,2ʹ-disulfonic Acid, 2Na
• Fórmula empírica (notación de Hill): C₁₆H₈N₂O₆S₄ · 2Na
• Número de CAS: 53005-05-3
• Peso molecular: 498.48
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• product name: DIDS, Disodium Salt, Binds covalently and irreversibly to the outer surface of human erythrocyte membranes.
• Quality Level: 100
• assay: ≥85% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated; protect from light
• color: yellow
• solubility: water: 0.5%
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24)/b2-1+
• InChI key: YSCNMFDFYJUPEF-OWOJBTEDSA-N

Descripción

General description

Binds covalently and irreversibly to the outer surface of human erythrocyte membrane proteins. Inhibits ATP transport into the endoplasmic reticulum vesicles. Anion transport inhibitor that inhibits Cl^- uptake (IC₅₀ = 150 nM) in neuroblastoma cells. Has antiulcerous activity.

Binds covalently and irreversibly to the outer surface of human erythrocyte membranes. Inhibits ATP transport into endoplasmic reticulum vesicles. Anion transport inhibitor that inhibits Cl^– uptake (IC₅₀ = 150 nM) in neuroblastoma cells. Has anti-ulcerous properties.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Cl- uptake

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 150 nM inhibiting Cl- uptake in neuroblastoma cells

Warning

Toxicity: Irritant (B)

Other Notes

Bettendorff, L., et al. 1995. Biochem. Biophys. Res. Commun. 207, 375.
Horie, S., et al. 1993. Res. Commun. Chem. Pathol. Pharmacol. 79, 117.
Mayinger, P., and Meyer, D.I. 1993. EMBO J. 12, 659.
Catantchik, Z.I., and Rothstein, A. 1974. J. Membr. Biol.15, 207.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable