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Key Documents

227016

Sigma-Aldrich

CCR2 Antagonist

≥97% (racemic mixture, HPLC), solid, CCR2 antagonist, Calbiochem®

Sinónimos:

CCR2 Antagonist, 2-((Isopropylaminocarbonyl)amino)-N-(2-((cis-2-((4-(methylthio)benzoyl)amino)cyclohexyl)amino)-2-oxoethyl)-5-(trifluoromethyl)-benzamide, CC Chemokine Receptor 2 Antagonist

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About This Item

Fórmula empírica (notación de Hill):
C28H34F3N5O4S
Número de CAS:
445479-97-0
Peso molecular:
593.66
UNSPSC Code:
12352200
NACRES:
NA.77

product name

CCR2 Antagonist, The CCR2 Antagonist, also referenced under CAS 445479-97-0, controls the biological activity of CCR2.

Quality Level

100

assay

≥97% (racemic mixture, HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

white

solubility

ethanol: 6 mg/mL
DMSO: 60 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

A cis-diamidocyclohexyl urea compound that potently competes against MCP-1 binding to CCR2 (IC50 = 5.1 nM) and effectively inhibits MCP-1/CCR2-mediated PBMCs Ca+2 flux and chemotaxis (IC50 = 18 and 1 nM, respectively), while showing much less effect against eotaxin binding to CCR3 (37% inhibition at 10 µM). Mutageneis analysis indicates CCR2 Thr292 is critical in maintaining the high affinity antagonist binding.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Preparation Note

Gentle warming, rapid stirring, and/or sonication may be required for complete solubilization.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Cherney, R.J., et al. 2008. J. Med. Chem.51, 721.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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