129876
Amiloride, Hydrochloride
An inhibitor of angiogenesis.
Sinónimos:
Amiloride, Hydrochloride, Acid-Sensing Ion Channel Modulator I, ASIC Channel Modulator I
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About This Item
Fórmula empírica (notación de Hill):
C6H8ClN7O · xHCl
Número de CAS:
Peso molecular:
229.63 (free base basis)
Número MDL:
Código UNSPSC:
12352200
NACRES:
NA.77
Productos recomendados
Nivel de calidad
descripción
Merck USA index - 14, 406
Ensayo
≥98% (HPLC)
Formulario
solid
fabricante / nombre comercial
Calbiochem®
condiciones de almacenamiento
OK to freeze
desiccated (hygroscopic)
protect from light
color
off-white to yellow
solubilidad
water: 2.5 mg/mL
DMSO: 5 mg/mL
Condiciones de envío
ambient
temp. de almacenamiento
10-30°C
cadena SMILES
Clc1nc(c(nc1N)N)C(=O)N\C(=N\[H])\N.Cl
InChI
1S/C6H8ClN7O.ClH/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;/h(H4,8,9,13)(H4,10,11,14,15);1H
Clave InChI
ACHKKGDWZVCSNH-UHFFFAOYSA-N
Descripción general
An inhibitor of angiogenesis. At low concentrations, acts as a potent and specific inhibitor of transmembrane Na+ entry and Na+/H+ ATPase. Inhibits smooth muscle responses to contractile stimuli. Blocks palytoxin-induced conductance in skeletal muscle. Reduces the electrical potential across tubular epithelium. At higher concentrations, blocks the Na+/H+ exchange pathway.
An inhibitor of angiogenesis. Inhibits capillary morphogenesis completely and reversibly at approximately 130 µM. At low concentrations, acts as a potent and specific inhibitor of transmembrane Na+ entry and Na+,K+-ATPase. Also acts as an inhibitor of urokinase-type plasminogen activator (uPA). Blocks smooth muscle responses to contractile stimuli and palytoxin-induced conductance in skeletal muscle. Reduces electrical potential across tubular epithelium. At higher concentrations, blocks the Na+/H+ exchange pathway.
Acciones bioquímicas o fisiológicas
Cell permeable: no
Primary Target
capillary morphogenesis
capillary morphogenesis
Product does not compete with ATP.
Reversible: yes
Target IC50: 130 µM inhibiting capillary morphogenesis completely and reversibly
Advertencia
Toxicity: Toxic (F)
Reconstitución
Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 6 months at -20°C.
Otras notas
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Knoll, A., et al. 1999. Microvasc. Res.58, 1.
Swiercz, R., et al. 1999. Oncol. Rep.6, 523.
Moran, A., et al. 1995. Am. J. Physiol. 268, C350.
Alliegro, M.C., et al. 1993. J. Exp. Zool. 267, 245.
Sugiyama, S., et al. 1988. J. Biol. Chem.263, 8215.
Yoshida, K., et al. 1988. Biochem. Biophys. Res. Commun.154, 101.
Sariban-Sotorabay, S., and Benos, D.J. 1986. Am. J. Physiol.250, C175.
Swiercz, R., et al. 1999. Oncol. Rep.6, 523.
Moran, A., et al. 1995. Am. J. Physiol. 268, C350.
Alliegro, M.C., et al. 1993. J. Exp. Zool. 267, 245.
Sugiyama, S., et al. 1988. J. Biol. Chem.263, 8215.
Yoshida, K., et al. 1988. Biochem. Biophys. Res. Commun.154, 101.
Sariban-Sotorabay, S., and Benos, D.J. 1986. Am. J. Physiol.250, C175.
Información legal
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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