123041

AICA-Riboside, 5′-Phosphate

A 5′-phosphorylated analog of membrane permeable AICA-Riboside that mimics AMP and acts as an activator of AMPK (AMP-activated protein kinase).

• Sinónimos: AICA-Riboside, 5′-Phosphate, AICA-Ribotide, AICAr Monophosphate, ZMP, AMPK Signaling Activator IV
• Fórmula empírica (notación de Hill): C₉H₁₅N₄O₈P
• Número de CAS: 3031-94-5
• Peso molecular: 338.21
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• color: white to light pink
• solubility: water: 1 mg/mL; DMSO: 30 mg/mL
• shipped in: wet ice
• storage temp.: −20°C
• InChI: 1S/C9H15N4O8P/c10-7-4(8(11)16)12-2-13(7)9-6(15)5(14)3(21-9)1-20-22(17,18)19/h2-3,5-6,9,14-15H,1,10H2,(H2,11,16)(H2,17,18,19)
• Inchi Key: NOTGFIUVDGNKRI-UHFFFAOYSA-N

Descripción

General description

A 5′-phosphorylated analog of membrane permeable AICA-Riboside (Cat. No. 123040) that mimics AMP and acts as an activator of AMPK (AMP-activated protein kinase).

A 5′-phosphorylated analog of membrane permeable AICA-Riboside (Cat. No. 123040) that mimics AMP and acts as an activator of AMPK (AMP-activated protein kinase).

Biochem/physiol Actions

Cell permeable: no

Primary Target
Activator of AMPK (AMP-activated protein kinase)

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Preparation Note

Only water soluble following extensive heating.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Fryer, L.G.D., et al. 2002. Biochem. J.363, 167.
Henin, N., et al. 1996. Biochim. Biophys. Acta1290, 197.
Corton, J.M., et al. 1995. Eur. J. Biochem.229, 558.
Sullivan, J.E., et al. 1994. Biochem. Biophys. Res. Commun.200, 1551.
Sabina, R.L., et al. 1985. J. Biol. Chem.260, 6107.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable