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H-004

Supelco

Hydromorphone solution

1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Fórmula empírica (notación de Hill):
C17H19NO3
Número de CAS:
466-99-9
Peso molecular:
285.34
EC Number:
200-659-6
MDL number:
MFCD00864214
UNSPSC Code:
41116107
PubChem Substance ID:
329815100
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

concentration

1 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

SMILES string

CN1CC[C@@]23[C@H]4CCC(=O)[C@@H]2Oc5c(O)ccc(C[C@@H]14)c35

InChI

1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,16,19H,3,5-8H2,1H3/t10-,11+,16-,17-/m0/s1

InChI key

WVLOADHCBXTIJK-YNHQPCIGSA-N

Gene Information

human ... OPRM1(4988)

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General description

A certified reference standard suitable for use as a starting material in calibrators or controls for a variety of LC/MS or GC/MS applications from forensic analysis, clinical toxicology, and pain prescription monitoring to urine drug testing and pharmaceutical research. Hydromorphone, marketed under brand names including Palladone and Dilaudid®, is a very potent opioid analgesic. The drug is often used medicinally as an alternative to morphine for treatment of pain or as a cough suppressant for painful coughing resulting from continued bronchial irritation.

Application


  • Quantitative analysis of Haloperidol: Development of a sensitive LC-MS/MS method for Haloperidol quantification in human plasma, employing Haloperidol-D₄ as an internal standard and incorporating phospholipid removal pretreatment to enhance detection accuracy (Zidekova et al., 2021).

  • Automated determination in toxicological studies: Utilization of Haloperidol-D₄ in an automated method for toxicokinetic studies of Trimebutine and its metabolites, demonstrating the compound′s role in high-throughput forensic toxicology (Larabi et al., 2015).

  • High-throughput drug monitoring: Application of ′high throughput′ solid-phase extraction and turbo ionspray LC-MS-MS for Haloperidol determination in plasma, showcasing the efficiency of Haloperidol-D₄ as a stable isotope-labeled standard for enhancing bioanalytical procedures (Hempenius et al., 1999).



Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Dilaudid is a registered trademark of Purdue Pharma L.P.

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H-010

Hydromorphone-D3 solution, 1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

H-006

Hydromorphone-D3 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

P-071

Pain Management Multi-component Opiate Mixture-13 solution, 100 μg/mL each component (10 μg/mL Fentanyl), ampule of 1.0 mL, certified reference material, Cerilliant®

H-049

Hydromorphone-D6 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

H-050

Hydromorphone-D6 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

H-051

Hydromorphone-3-β-D-glucuronide, 100 μg/mL in methanol: water (1:1), ampule of 1 mL, certified reference material, Cerilliant®

N-107

Norhydromorphone hydrochloride solution, 1.0 mg/mL in methanol (as free base), certified reference material, ampule of 1 mL, Cerilliant®

H-004S

Hydromorphone solution, 1 mg/mL in methanol, certified reference material, ampule of 1 mL, Cerilliant®

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Christoph Mans et al.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 43(3), 662-665 (2012-10-23)
Despite the frequent clinical use of buprenorphine in reptiles, its antinociceptive efficacy is not known. In a randomized, complete cross-over study, the antinociceptive efficacy of buprenorphine (0.2 mg/kg s.c.) was compared with hydromorphone (0.5 mg/kg s.c.), and saline (0.9% s.c.
Erica Suzan et al.
Pain physician, 16(1), 65-76 (2013-01-24)
Opioids are the cornerstone therapy for the treatment of moderate to severe pain. Yet, unconfirmed evidence suggests that chronic exposure to opioids may cause hypersensitivity to pain, a phenomenon known as opioid-induced hyperalgesia (OIH). The current preliminary prospective study was
Teijo I Saari et al.
Journal of pharmaceutical and biomedical analysis, 71, 63-70 (2012-08-14)
A method for a sensitive and specific analysis of hydromorphone total and unbound drug concentrations in human plasma was developed and validated. Sample preparation was preceded with an ultrafiltration step to separate the unbound drug from the protein bound fraction
Andrew K Chang et al.
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 20(2), 185-192 (2013-02-15)
The objective was to test the efficacy and safety of 2 mg of intravenous (IV) hydromorphone (Dilaudid) against "usual care" in emergency department (ED) patients with acute severe pain. This was a randomized clinical trial. Patients allocated to 2 mg
Srinivas Nalamachu et al.
Journal of opioid management, 9(1), 43-49 (2013-05-28)
To assess the efficacy and safety of once-daily hydromorphone extended-release tablets (OROS [Alza Corporation, Mountain View, CA] hydromorphone ER) in patients with chronic neuropathic pain. Single-center, open-label, 12-week study. Opioid-tolerant patients with chronic neuropathic pain for $6 months (N =
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