D-055

N-Desethylamiodarone hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

• Fórmula empírica (notación de Hill): C₂₃H₂₆ClI₂NO₃
• Número de CAS: 96027-74-6
• Peso molecular: 653.72
• EC Number: 200-659-6
• MDL number: MFCD08060094
• UNSPSC Code: 41116107
• PubChem Substance ID: 329798619
• NACRES: NA.24

Propiedades

• grade: certified reference material
• Quality Level: 300
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 1.0 mg/mL in methanol (as free base)
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): clinical testing
• format: single component solution
• storage temp.: −20°C
• SMILES string: IC1=CC(C(C2=C(CCCC)OC3=CC=CC=C23)=O)=CC(I)=C1OCCNCC.Cl
• InChI: 1S/C23H25I2NO3.ClH/c1-3-5-9-20-21(16-8-6-7-10-19(16)29-20)22(27)15-13-17(24)23(18(25)14-15)28-12-11-26-4-2;/h6-8,10,13-14,26H,3-5,9,11-12H2,1-2H3;1H
• InChI key: OCQPMJVGWGJLLG-UHFFFAOYSA-N

Descripción

General description

A Certified Spiking Solution^® for use in therapeutic drug monitoring analyses by HPLC or LCMS. N-Desethylamiodarone is the primary, active metabolite of amiodarone, an antiarrhythmic agent marketed as Pacerone^®, Cordarone^®, Aratac, and Atlansil and monitored by clinical labs to ensure patients remain within the drugs therapeutic range.

Application

• Impact on Amiodarone Absorption: A study examining the effects of probiotics on drug pharmacokinetics demonstrated that E. coli Nissle 1917 alters the absorption of amiodarone in rats, which suggests implications for N-Desethylamiodarone hydrochloride, a metabolite of amiodarone, in similar biochemical studies. This provides valuable insights for research into the metabolic pathways and interactions of amiodarone derivatives (Matuskova et al., 2014).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Cordarone is a registered trademark of Sanofi S.A.

Pacerone is a registered trademark of Upsher-Smith Laboratories, Inc.

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• pictograms: GHS02,GHS06,GHS08
• signalword: Danger
• hcodes: H225,H301 + H311 + H331,H370
• pcodes: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• target_organs: Eyes
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 1
• flash_point_f: 49.5 °F - closed cup
• flash_point_c: 9.7 °C - closed cup