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Key Documents

A-144

Supelco

Acylcarnitines Mix 2 (C4,iC4,C5,iC5,C6,C8,C10,C12,C14,C18) solution

100-200 μg/mL (90:10 Methanol: 1% aqueous formic acid), certified reference material, ampule of 1 mL, Cerilliant®

Sinónimos:

Acylcarnitines Mix 2 Solution

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About This Item

Fórmula empírica (notación de Hill):
C25H49NO4
Peso molecular:
427.66
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

composition

Butyryl-L-carnitine, 100 μg/mL
Decanoyl-L-carnitine, 100 μg/mL
Hexanoyl-L-carnitine, 100 μg/mL
Isobutyryl-L-carnitine, 100 μg/mL
Isovaleryl-L-carnitine, 100 μg/mL
Lauroyl-L-carnitine, 100 μg/mL
Myristoyl-L-carnitine, 100 μg/mL
Octanoyl-L-carnitine, 100 μg/mL
Stearoyl-L-carnitine, 200 μg/mL
Valeryl-L-carnitine, 100 μg/mL

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

100-200 μg/mL (90:10 Methanol: 1% aqueous formic acid)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

multi-component solution

storage temp.

−70°C

General description

A Certified Spiking Solution® of routinely tested Butyryl-L-Carnitine, Isobutyryl-L-Carnitine, Valeryl-L-Carnitine, Isovaleryl-L-Carnitine, Hexanoyl-L-Carnitine, Octanoyl-L-Carnitine, Decanoyl-L-Carnitine, Lauroyl-L-Carnitine, Myristoyl-L-Carnitine and Stearoyl-L-Carnitine at concentrations of 100-200 μg/mL. Acylcarnitines are biomarker for many inborn errors of metabolism that cause several metabolic diseases and are routinely tested in newborn screening programs. This multi-component mix is suitable for critical quantitative applications in research and clinical environments including: for use in preparation of controls, calibrators, and linearity standards for LC-MS/MS assays; as system tuning/suitability standards; linearity verification; and internal proficiency testing. The stable, quantitative solution format provides significant benefits to the user such as convenience of use, material savings, and increased efficiency of labor. Certified concentration values for each component provides increased efficiency from less time remaking pools due to dilution errors or rerunning samples.

Application


  • Metabolic Disorder Biomarker Development: Acylcarnitines are crucial in diagnosing very long-chain acyl-CoA dehydrogenase deficiency. This research utilizes acylcarnitine profiles to improve understanding and treatment approaches for metabolic disorders, employing mass spectrometry metabolites for precise analysis (Bleeker JC et al., 2020).

  • High-Purity Acylcarnitine Standards in Research: The study demonstrate the simultaneous extraction of metabolomes and lipidomes, including acylcarnitines, using ultra-high performance liquid chromatography/mass spectrometry. This methodology supports high-precision studies in fatty acid oxidation and metabolic assay development (Chen S et al., 2013).

  • Application in Inborn Errors of Metabolism Assay: The research investigates how dietary bioactive polyphenols affect the mitochondrial carnitine acylcarnitine carrier, showcasing the utility of acylcarnitines in studying the impact of natural compounds on metabolic pathways, vital for understanding inborn errors of metabolism (Console L et al., 2019).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Artículos

In this article we provide a complete workflow of quantification and identification of acylcarnitines in dried blood spots (DBS) using stable isotope-labeled (SIL) acylcarnitines CRMs by FIA-MS/MS.

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