700015P

7-ketocholesterol

Avanti Research^™ - A Croda Brand

• Sinónimos: 7-oxocholesterol; 7-oxo-5-cholesten-3β-ol-7-one; 5-cholesten-3β-ol-7-one; 3β-hydroxycholest-5-en-7-one; 110806
• Fórmula empírica (notación de Hill): C₂₇H₄₄O₂
• Número de CAS: 566-28-9
• Peso molecular: 400.64
• Número MDL: MFCD00010474
• Código UNSPSC: 12352211
• NACRES: NA.25

Propiedades

• descripción: 3β-hydroxy-5-cholestene-7-one
• Ensayo: >99% (TLC)
• Formulario: powder
• envase: pkg of 1 × 100 mg (700015P-100mg); pkg of 1 × 5 mg (700015P-5mg); pkg of 1 × 50 mg (700015P-50mg)
• fabricante / nombre comercial: Avanti Research^™ - A Croda Brand
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• cadena SMILES: O[C@H]1CC[C@@]2([C@@H]3[C@H]([C@H]4[C@@]([C@H](CC4)[C@@H](CCCC(C)C)C)(CC3)C)C(=O)C=C2C1)C
• InChI: 1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h16-18,20-23,25,28H,6-15H2,1-5H3/t18-,20+,21-,22+,23+,25+,26+,27-/m1/s1
• Clave InChI: YIKKMWSQVKJCOP-ABXCMAEBSA-N

Descripción

Descripción general

7-ketocholesterol is a major oxidation product of cholesterol.

Aplicación

<ul>
<li><strong>Cytoprotective effects of linolenic acid on 7-ketocholesterol-induced damage:</strong> This study highlights how specific fatty acids can mitigate the toxic effects of 7-ketocholesterol in neural and vascular cells, emphasizing potential therapeutic applications for neurodegenerative and cardiovascular diseases (Yammine et al., 2024).</li>
</ul>

Acciones bioquímicas o fisiológicas

7-ketocholesterol is a strong inhibitor of cytochrome P450 7A1. It modulates cholesterol homeostasis, cytotoxicity and apoptosis. 7-ketocholesterol stimulates inflammation, growth inhibition and vascular endothelial growth factor. Cellular accumulation of 7-ketocholesterol enhances oxidative stress, endoplasmic reticulum stress and apoptosis in macrophages.

Envase

5 mL Amber Glass Screw Cap Vial (700015P-100mg)

5 mL Amber Glass Screw Cap Vial (700015P-50mg)

5 mL Amber Glass Screw Cap Vial (700015P-5mg)

Información legal

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable