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Key Documents

933082

Sigma-Aldrich

NanoFabTx™ NanoFlash PEG-PLA drug formulation screening kit

for CIJ synthesis of nanoparticles

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About This Item

UNSPSC Code:
12162002
NACRES:
NA.21

Application

NanoFabTx™ NanoFlash PEG-PLA drug formulation screening kit is a ready to use nanoformulation kit for flash nanoprecipitation synthesis of PEGylated PLA nanoparticles for drug delivery research applications. This kit contains rationally selected PEGylated PLA polymers and stabilizer, enabling users to screen and select nanoformulations without the need for lenghty trial and error optimization. These PEGylated PLA polymers have been widely used in drug delivery systems for controlled drug release of many different types of therapeutic molecules.

This kit has been curated and designed for flash nanoprecipitiaton (FNP) nanoparticle synthesis using a confined impingement jet (CIJ) mixer, such as the NanoFabTx™ NanoFlash CIJ Mixer, and detailed step-by-step instructions are provided.

Features and Benefits

  • Ready-to-use nanoformulation kit for PEGylated nanoparticles
  • Step-by-step flash nanoprecipitation protocol
  • Create specifically sized, biodegradable, PEGylated PLA nanoparticles
  • Maximize the encapsulation of hydrophobic drugs
  • Two different PEGylated PLAs are included
  • Optimized for 60 nm-150 nm nanoparticles
A flash nanoprecipitation protocol to prepare drug-encapsulated nanoparticles using the NanoFabTx™ NanoFlash CIJ Mixer is included and can be found under the Protocol section of this page.

Legal Information

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Jing Han et al.
Journal of pharmaceutical sciences, 101(10), 4018-4023 (2012-07-11)
Johnson and Prud'homme (2003. AICHE J 49:2264-2282) introduced the confined impingement jets (CIJ) mixer to prepare nanoparticles loaded with hydrophobic compounds (e.g., drugs, inks, fragrances, or pheromones) via flash nanoprecipitation (FNP). We have modified the original CIJ design to allow
C Thomasin et al.
Journal of pharmaceutical sciences, 87(3), 269-275 (1998-04-02)
Phase separation (frequently called coacervation) of poly(lactide) (PLA) and poly(lactide-co-glycolide) (PLGA) is a classical method for drug microencapsulation. Here, attempts have been made to describe this process in the light of thermodynamics. Different PLA/PLGAs were dissolved in either dichloromethane or
Robert F Pagels et al.
Journal of controlled release : official journal of the Controlled Release Society, 219, 519-535 (2015-09-12)
Biologically derived therapeutics, or biologics, are the most rapidly growing segment of the pharmaceutical marketplace. However, there are still unmet needs in improving the delivery of biologics. Injectable polymeric nanoparticles and microparticles capable of releasing proteins and peptides over time
Verónica Lassalle et al.
Macromolecular bioscience, 7(6), 767-783 (2007-06-02)
The controlled release of medicaments remains the most convenient way of drug delivery. Therefore, a wide variety of reports can be found in the open literature dealing with drug delivery systems. In particular, the use of nano- and microparticles devices
Byung Kook Lee et al.
Advanced drug delivery reviews, 107, 176-191 (2016-06-06)
Poly(d,l-lactic acid) (PLA) has been widely used for various biomedical applications for its biodegradable, biocompatible, and nontoxic properties. Various methods, such as emulsion, salting out, and precipitation, have been used to make better PLA micro- and nano-particle formulations. They are
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