860581
α-Methyl-α-phenylsuccinimide
99%
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About This Item
Fórmula empírica (notación de Hill):
C11H11NO2
Número de CAS:
Peso molecular:
189.21
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Productos recomendados
assay
99%
form
solid
mp
83-85 °C (lit.)
functional group
phenyl
SMILES string
CC1(CC(=O)NC1=O)c2ccccc2
InChI
1S/C11H11NO2/c1-11(7-9(13)12-10(11)14)8-5-3-2-4-6-8/h2-6H,7H2,1H3,(H,12,13,14)
InChI key
UDESUGJZUFALAM-UHFFFAOYSA-N
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Arcadius V Krivoshein
ACS chemical neuroscience, 7(3), 316-326 (2016-01-08)
Although the antiepileptic properties of α-substituted lactams, acetamides, and cyclic imides have been known for over 60 years, the mechanism by which they act remains unclear. I report here that these compounds bind to the nicotinic acetylcholine receptor (nAChR) and
D A Coulter et al.
British journal of pharmacology, 100(4), 807-813 (1990-08-01)
1. Currents evoked by applications of gamma-aminobutyric acid (GABA) to acutely dissociated thalamic neurones were analysed by voltage-clamp techniques, and the effects of the anticonvulsant succinimides ethosuximide (ES) and alpha-methyl-alpha-phenylsuccinimide (MPS) and the convulsants tetramethylsuccinimide (TMS), picrotoxin, pentylenetetrazol (PTZ), and
J C Gomora et al.
Molecular pharmacology, 60(5), 1121-1132 (2001-10-20)
Inhibition of T-type Ca(2+) channels has been proposed to play a role in the therapeutic action of succinimide antiepileptic drugs. Despite the widespread acceptance of this hypothesis, recent studies using rat and cat neurons have failed to confirm inhibition of
J M Streete et al.
Therapeutic drug monitoring, 17(3), 280-286 (1995-06-01)
Analysis of desmethylmethsuximide by high-performance liquid chromatography (HPLC) is described. After adding an internal standard (IS), 200 microliters of plasma was buffered to pH 4.5 and extracted with dichloroethane. The organic solvent was then evaporated to dryness and the residue
D A Coulter et al.
British journal of pharmacology, 100(4), 800-806 (1990-08-01)
1. Succinimide derivatives can be either convulsant (tetramethylsuccinimide (TMS)), or anticonvulsant (ethosuximide (ES); alpha-methyl-alpha-phenylsuccinimide (MPS)). ES, an anticonvulsant succinimide, has previously been shown to block calcium currents of thalamic neurones, while the convulsant succinimide TMS blocks gamma-aminobutyric acid (GABA) responses
Chromatograms
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