If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf
741965
Gold nanoparticles
20 nm diameter, OD 1, stabilized suspension in citrate buffer
Sinónimos:
Au NP, Gold Colloid
About This Item
Productos recomendados
Nivel de calidad
Formulario
nanoparticles
suspension
contiene
Proprietary Surfactant as stabilizer
concentración
~6.54E+11 particles/mL
DO
1
diámetro
20 nm
λmáx.
518-522 nm
PDI
<0.2
temp. de almacenamiento
2-8°C
cadena SMILES
[Au]
InChI
1S/Au
Clave InChI
PCHJSUWPFVWCPO-UHFFFAOYSA-N
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Descripción general
Aplicación
- neutrophil labeling for monitoring the effect of different drugs[7]
- immobilization of proteins for biosensor applications[8]
- nano-carrier for drug delivery system for the release of hydrophobic drugs.[4]
This material is highly monodisperse (<12% variability in size and shape), and provides significantly improved surface reactivity. Applications include Surface Enhanced Raman Lables, Sensing/Detection, Biological Targeting, Plasmonics and Electronics.
Información legal
Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
nwg
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Artículos
Steven J. Oldenburg, Ph.D. provides an overview of lateral flow diagnostic assays and discusses the use of ultra-bright reporter particles based on the unique optical properties of gold nanoshells that significantly increase the sensitivity of lateral flow immunoassays.
Steven J. Oldenburg, Ph.D. provides an overview of lateral flow diagnostic assays and discusses the use of ultra-bright reporter particles based on the unique optical properties of gold nanoshells that significantly increase the sensitivity of lateral flow immunoassays.
Sustainable energy sources with high production efficiency are crucial for meeting increasing energy demand.
Steven J. Oldenburg, Ph.D. provides an overview of lateral flow diagnostic assays and discusses the use of ultra-bright reporter particles based on the unique optical properties of gold nanoshells that significantly increase the sensitivity of lateral flow immunoassays.
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How can I determine the shelf life / expiration / retest date of this product?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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The AuNPs in citrate do not change color when with NaCl. What can I do? Do you have any recommendation of what protocol can I use to functionalize citrate AuNPs 20nm?
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The color change of AuNPs when mixed with NaCl is typically due to the aggregation of AuNPs. However, this product contains citrate buffer as a stabilizer, so a small amount of NaCl will not lead to aggregation. Increasing the amount of NaCl or performing a solvent exchange to remove the citrate buffer may induce a color change, but this is not recommended as the aggregated AuNPs may not be able to be re-dispersed. Unfortunately, no protocol is available to functionalize the AuNPs.
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What is the molarity of this solution (ref: 741965)?"
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The concentration for this product is listed as ~6.54E+11 particles/mL. The concentration in g/mol is not determined.
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My solution of 5nm gold nanoparticles has turned from red to purple. This would indicate aggregation. What caused this and how can I reverse the aggregation? The nanoparticles are stored in a fridge at 5 degrees C.
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The information below regarding the color change and aggregation is provided by the manufacturer:
The gold nanoparticle solution turns violet when I add salt-containing buffer. Why is that?
Due to repulsive forces arising from the surface charge of gold nanoparticles, an energy barrier must be overcome for individual particles to interact.
When no (or small) amounts of electrolytes such as NaCl are present, this energy barrier is too strong for interaction to occur between particles. However, upon the addition of NaCl, this energy barrier is reduced allowing the gold nanoparticles to interact and aggregate. This aggregation causes a phenomenon called surface-plasmon coupling which changes the adsorption maximum of light to a higher wavelength resulting in a change in the color of the solution.Gold Nanoparticle Aggregation
The aggregation state of gold nanoparticles has an effect on their optical properties. This fact can be used to monitor gold nanoparticle stability, both over time, and upon the addition of salt-containing buffers, which at high enough concentrations cause particle aggregation, figure 5. The red-shift in absorption maximum caused by aggregation, or particles in close proximity, has successfully been utilized in many assays as a detection mechanism.See the image below for details on the effects of aggregation on color change and wavelength.
To discuss this further, please we kindly ask you to navigate to the link https://www.sigmaaldrich.com/techservice and click on "Report Product Issues" under the Products Section with all the required information so that a member of our team can reach out to you to assist further. Thank you.
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Which technique is used for the synthesis of these Gold nanoparticles?
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This product has a quality level 100. The preparation and synthesis is proprietary for products with a quality level under 400.
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My gold nanoparticles settle out of solution upon storage. Is this normal?
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Settling of gold nanoparticles on the bottom of the storage flask is completely normal and is especially common for larger sized particles, which settles at greater speed. Settling does not affect the performance of the particles. Prior to use, simply swirl the solution to properly disperse your gold nanoparticles and obtain a homogenous solution.
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Why does my gold nanoparticle solution turn violet when I add salt containing buffer?
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Due to repulsive forces arising from the surface charge of gold nanoparticles, an energy barrier must be overcome for individual particles to interact. When no (or small) amounts of electrolytes such as NaCl is present, this energy barrier is too strong for interaction to occur between particles. However, upon addition of NaCl this energy barrier is reduced allowing the gold nanoparticles to interact and aggregate. This aggregation causes a phenomenon called surface-plasmon coupling which changes the adsorption maximum of light to a higher wavelength resulting in a change in color of the solution.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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How do you attach gold nanoparticles to oligos?
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To attach gold nanoparticles to oligos please view the information in the attached reference - Bioconjug Chem. 2011 Apr 20;22(4):794-807. Epub 2011 Mar 28.
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